Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats

被引：11
作者：
Fouad, Amr A. [1 ]
Moussa, Nardin A. [2 ]
Kareem, Mustafa M. Abdul [2 ]
Akl, Usama, I [3 ]
Abdelghany, Manal, I [4 ]
Abdel-Aziz, Asmaa M. [5 ]
机构：
[1] Al Baha Univ, Fac Med, Dept Pharmacol, Al Baha, Saudi Arabia
[2] Alexandria Univ, Fac Med, Student Res Comm, Alexandria, Egypt
[3] Al Baha Univ, Fac Med, Dept Surg, Al Baha, Saudi Arabia
[4] Minia Univ, Fac Med, Dept Pathol, El Minia, Egypt
[5] Minia Univ, Fac Med, Dept Pharmacol, El Minia, Egypt
来源：
PHARMACIA | 2022年 / 69卷 / 01期
关键词：
thymol; gentamicin; kidney; rats; INFLAMMATION; CISPLATIN; STRESS;
D O I：
10.3897/pharmacia.69.e77338
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The renoprotective effect of thymol (TML) was investigated in rats challenged with gentamicin (GN). Rats received TML (20 mg/ kg/day, p.o.) for 15 days, and GN (80 mg/kg/day, i.p.) starting from the 8th day. TML significantly lowered serum creatinine and neutrophil gelatinase-associated lipocalin, and renal malondialdehyde, nitric oxide, tumor necrosis factor-alpha, interleukin-18, Bax, caspase-3, and caspase-9 in GN-challenged rats. In addition, TML caused a significant increment of renal total antioxidant capacity in rats received GN. Moreover, TML significantly ameliorated GN-induced histopathological kidney tissue injury, and significantly decreased nuclear factor-kappa B p65 and kidney injury molecule-1 expressions in kidneys of GN-challenged rats. It was concluded that TML guarded against CN-induced nephrotoxicity in rats via inhibition of oxidative stress, inflammation, and apoptosis.
引用
收藏
页码：181 / 186
页数：6
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