Growth of Hydroxyapatite Coating on Polymer Microspheres

被引：4
作者：
Zhe, Zhang [1 ]
Zhang, Sam [1 ]
Venkatraman, Subbu S. [2 ]
Lei, Shang [2 ]
机构：
[1] Nanyang Technol Univ, Sch Mech & Aerosp Engn, Singapore 639798, Singapore
[2] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore
来源：
NANOSCIENCE AND NANOTECHNOLOGY LETTERS | 2011年 / 3卷 / 04期
关键词：
Poly(lactic-co-glycolic acid) Microspheres; Biomimetic; Hydroxyapatite Coating; Drug Delivery; PROTEIN;
D O I：
10.1166/nnl.2011.1204
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Hydroxyapatite (HA) coated polymer microspheres was prepared by a two-step process under physiological temperature and pH value. A full coverage of plate-like structured HA coating was achieved on poly(lactic-co-glycolic acid) (PLGA) microspheres. Field emission scanning electron microscopy was employed to observe the surface morphology of microspheres before and after coating. Fourier Transform Infrared spectra and X-ray diffraction were used for the chemical groups and crystal structure examination. The HA coated PLGA microspheres have potential applications in controlled drug delivery systems.
引用
收藏
页码：472 / 476
页数：5
相关论文
共 23 条
  • [1] Effect of glycerol-L-lactide coating polymer on bone ingrowth of bFGF-coated hydroxyapatite implants
    Alt, V
    Pfefferle, HJ
    Kreuter, J
    Stahl, JP
    Pavlidis, T
    Meyer, C
    Mockwitz, J
    Wenisch, S
    Schnettler, R
    [J]. JOURNAL OF CONTROLLED RELEASE, 2004, 99 (01) : 103 - 111
  • [2] An experimental bone defect healing with hydroxyapatite coating plasma sprayed on carbon/carbon composite implants
    Cao, Ning
    Dong, Jianwen
    Wang, Qiangxiu
    Ma, Quansheng
    Xue, Chengqian
    Li, Musen
    [J]. SURFACE & COATINGS TECHNOLOGY, 2010, 205 (04) : 1150 - 1156
  • [3] In vitro response of MC3T3-E1 preosteoblasts within three-dimensional apatite-coated PLGA scaffolds
    Chou, YF
    Dunn, JCY
    Wu, BM
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2005, 75B (01) : 81 - 90
  • [4] Biomimetic calcium phosphate coatings on Polyactive® 1000/70/30
    Du, C
    Klasens, P
    Haan, RE
    Bezemer, J
    Cui, FZ
    de Groot, K
    Layrolle, P
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 59 (03): : 535 - 546
  • [5] Surface-Functionalized Polymeric Nanoparticles as Templates for Biomimetic Mineralization of Hydroxyapatite
    Ethirajan, Anitha
    Ziener, Ulrich
    Landfester, Katharina
    [J]. CHEMISTRY OF MATERIALS, 2009, 21 (11) : 2218 - 2225
  • [6] Bond strength determination of hydroxyapatite coatings on Ti-6Al-4V substrates using the LAser Shock Adhesion Test (LASAT)
    Guipont, Vincent
    Jeandin, Michel
    Bansard, Sebastien
    Khor, Khiam Aik
    Nivard, Mariette
    Berthe, Laurent
    Cuq-Lelandais, Jean-Paul
    Boustie, Michel
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2010, 95A (04) : 1096 - 1104
  • [7] Osteoinduction by biomaterials - Physicochemical and structural influences
    Habibovic, P
    Sees, TM
    van den Doel, MA
    van Blitterswijk, CA
    de Groot, K
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 77A (04) : 747 - 762
  • [8] Rapid biomineralization of chitosan microparticles to apply in bone regeneration
    Jayasuriya, A. Champa
    Kibbe, Shane
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2010, 21 (02) : 393 - 398
  • [9] Mineral-Coated Polymer Microspheres for Controlled Protein Binding and Release
    Jongpoiboonkit, Leenaporn
    Franklin-Ford, Travelle
    Murphy, William L.
    [J]. ADVANCED MATERIALS, 2009, 21 (19) : 1960 - 1963
  • [10] Preparation and characterization of cationic PLGA nanospheres as DNA carriers
    Kumar, MNVR
    Bakowsky, U
    Lehr, CM
    [J]. BIOMATERIALS, 2004, 25 (10) : 1771 - 1777
123