One-Pot Synthesis of Fused Pyridazino[4,5-b][1,4]oxazepine-diones via Smiles Rearrangement

被引：21

作者：

Liu, Yanli ^{[1
]}

Ma, Ying ^{[1
]}

Zhan, Chunjing ^{[1
]}

Huang, Aiping ^{[1
]}

Ma, Chen ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

SYNLETT | 2012年 / 02期

基金：

美国国家科学基金会;

关键词：

pyridazino[4,5-b][1,4]oxazepine-dione; one-pot; synthesis; Smiles rearrangement; tandem reaction; 5-HT1A RECEPTOR AGONISTS; DERIVATIVES; INHIBITORS;

D O I：

10.1055/s-0031-1290073

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fused pyridazino[4,5-b][1,4]oxazepine-diones were easily obtained in moderate to excellent yields via Smiles rearrangement. The synthetic approach is supported by a one-pot coupling-Smiles rearrangement-cyclization process. This process has potential applications in the synthesis of biologically and medicinally relevant compounds.

引用

页码：255 / 258

页数：4

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