Mucosa-associated lymphoid tissue in individuals with AIDS

被引：1

作者：

Pacheco Olegario, Janainna Grazielle

Rossi e Silva, Renata Calciolari ^{[2
]}

Antunes Teixeira, Vicente de Paula ^{[1
]}

da Cunha Castro, Eumenia Costa

Miranda Correa, Rosana Rosa ^{[1
]}

机构：

[1] Univ Fed Triangulo Mineiro, Disciplina Patol Geral, BR-38025180 Uberaba, MG, Brazil

[2] Univ Oeste Paulista UNOESTE, Presidente Prudente, Brazil

来源：

BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY | 2011年 / 77卷 / 03期

关键词：

acquired immunodeficiency syndrome; fibrosis; immunoglobulins; lymphoid tissue; REGULATORY T-CELLS; PAROTID-SALIVA; IGA SUBCLASSES; IMMUNE-SYSTEM; HIV-INFECTION; FIBROSIS; CD4(+); SERUM;

D O I：

10.1590/S1808-86942011000300007

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Vestibular folds (VF) protect upper airways, but contain fewer immune cells in AIDS patients, which affects the structure of lymphoid follicles (LF). Objective: To characterize fibrosis and immunoglobulin production in vestibular fold lymphoid tissues of AIDS patients with or with no infection and malnutrition. Materials and Methods: A retrospective study of 71 adult vestibular fold autopsy specimens. The morphological analysis was done using the picrosirius staining method. Immunohistochemical methods consisted of anti-IgA, anti IgG, and anti IgM antibodies. Results: Fibrosis was less intense in AIDS patients compared to subjects without AIDS; the same applied to patients with infection or malnutrition. IgA and IgG titers were higher in AIDS patients; IgM titers were higher in cases with infection. Conclusion: This study helps understand variations in lymphoid follicle components of AIDS patients; it also shows the influence of architectural changes and the effect of associated respiratory infection and malnutrition on lymphoid follicle function.

引用

页码：308 / 314

页数：7

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