Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: Towards a harmonized segmentation protocol

被引：238

作者：

Yushkevich, Paul A. ^{[1
]}

Amaral, Robert S. C. ^{[2
]}

Augustinack, Jean C. ^{[3
]}

Bender, Andrew R. ^{[4
]}

Bernstein, Jeffrey D. ^{[5
,6
]}

Boccardi, Marina ^{[7
]}

Bocchetta, Martina ^{[7
,8
]}

Burggren, Alison C. ^{[9
]}

Carr, Valerie A. ^{[10
]}

Chakravarty, M. Mallar ^{[2
,11
]}

Chetelat, Gael ^{[12
]}

Daugherty, Ana M. ^{[4
,13
]}

Davachi, Lila ^{[14
,15
]}

Ding, Song-Lin ^{[16
]}

Ekstrom, Arne ^{[17
,18
]}

Geerlings, Mirjam I. ^{[19
]}

Hassan, Abdul ^{[17
]}

Huang, Yushan ^{[20
]}

Iglesias, J. Eugenio ^{[3
,21
]}

La Joie, Renaud ^{[12
]}

Kerchner, Geoffrey A. ^{[5
,6
]}

LaRocque, Karen F. ^{[10
]}

Libby, Laura A. ^{[17
]}

Malykhin, Nikolai ^{[20
,22
]}

Mueller, Susanne G. ^{[23
,24
]}

Olsen, Rosanna K. ^{[25
]}

Palombo, Daniela J. ^{[26
]}

Parekh, Mansi B. ^{[27
]}

Pluta, John B. ^{[1
,28
]}

Preston, Alison R. ^{[29
,30
,31
]}

Pruessner, Jens C. ^{[32
,33
]}

Ranganath, Charan ^{[17
,18
]}

Raz, Naftali ^{[4
,13
]}

Schlichting, Margaret L. ^{[29
,30
]}

Schoemaker, Dorothee ^{[32
,33
]}

Singh, Sachi ^{[34
]}

Stark, Craig E. L. ^{[35
]}

Suthana, Nanthia ^{[36
]}

Tompary, Alexa ^{[14
]}

Turowski, Marta M. ^{[34
]}

Van Leemput, Koen ^{[3
,37
]}

Wagner, Anthony D. ^{[10
,38
]}

Wang, Lei ^{[34
,39
]}

Winterburn, Julie L. ^{[2
]}

Wisse, Laura E. M. ^{[4
]}

Yassa, Michael A. ^{[35
]}

Zeineh, Michael M. ^{[27
]}

机构：

[1] Univ Penn, Dept Radiol, Penn Image Comp & Sci Lab, Philadelphia, PA 19104 USA

[2] McGill Univ, Douglas Mental Hlth Univ Inst, Cerebral Imaging Ctr, Montreal, PQ H3A 2T5, Canada

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Radiol,AA Martinos Ctr Biomed Imaging, Cambridge, MA 02138 USA

[4] Wayne State Univ, Inst Gerontol, Detroit, MI 48202 USA

[5] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[6] Stanford Ctr Memory Disorders, Stanford, CA USA

[7] IRCCS, Ctr S Giovanni Dio Fatebenefratelli, LENITEM, Brescia, Italy

[8] Univ Brescia, Dept Mol & Translat Med, Brescia, Italy

[9] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA

[10] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA

[11] McGill Univ, Dept Biomed Engn, Dept Psychiat, Montreal, PQ H3A 2T5, Canada

[12] Univ Caen Basse Normandie, CHU Caen, Ecole Prat Hautes Etud, INSERM U1077,UMR S1077, Caen, France

[13] Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA

[14] NYU, Dept Psychol, New York, NY 10003 USA

[15] NYU, Ctr Neural Sci, New York, NY 10003 USA

[16] Allen Inst Brain Sci, Seattle, WA USA

[17] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA

[18] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA

[19] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[20] Univ Alberta, Dept Biomed Engn, Edmonton, AB, Canada

[21] Basque Ctr Cognit Brain & Language BCBL, Donostia San Sebastian, Spain

[22] Univ Alberta, Ctr Neurosci, Edmonton, AB, Canada

[23] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[24] San Francisco VA Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA USA

[25] Rotman Res Inst, Baycrest, ON, Canada

[26] VA Boston Healthcare Syst, Boston, MA USA

[27] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

[28] Univ Penn, Dept Biostat, Philadelphia, PA 19104 USA

[29] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA

[30] Univ Texas Austin, Ctr Learning & Memory, Austin, TX 78712 USA

[31] Univ Texas Austin, Dept Neurosci, Austin, TX 78712 USA

[32] McGill Univ, Fac Med, McGill Ctr Studies Aging, Montreal, PQ H3A 2T5, Canada

[33] McGill Univ, Dept Psychol, Montreal, PQ H3A 2T5, Canada

[34] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Evanston, IL 60208 USA

[35] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA USA

[36] Univ Calif Los Angeles, Dept Neurosurg, Los Angeles, CA 90024 USA

[37] Tech Univ Denmark, Dept Appl Math & Comp Sci, Odense, Denmark

[38] Stanford Univ, Neurosci Program, Stanford, CA 94305 USA

[39] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Evanston, IL 60208 USA

来源：

NEUROIMAGE | 2015年 / 111卷

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会; 美国国家卫生研究院;

关键词：

Hippocampus; Medial temporal lobe; Hippocampal subfields; CA1; CA2; CA3; Dentate gyrus; Subiculum; Entorhinal cortex; Perirhinal cortex; Parahippocampal gyrus; Magnetic resonance imaging; Segmentation; Unified protocol; MEDIAL TEMPORAL-LOBE; HIGH-RESOLUTION MRI; MILD COGNITIVE IMPAIRMENT; APICAL NEUROPIL ATROPHY; ALZHEIMERS-DISEASE; VOLUMETRIC-ANALYSIS; FUNCTIONAL MRI; DENTATE GYRUS; CORTEX; AGE;

D O I：

10.1016/j.neuroimage.2015.01.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: An increasing number of human in vivo magnetic resonance imaging (MRI) studies have focused on examining the structure and function of the subfields of the hippocampal formation (the dentate gyrus, CA fields 1-3, and the subiculum) and subregions of the parahippocampal gyrus (entorhinal, perirhinal, and parahippocampal cortices). The ability to interpret the results of such studies and to relate them to each other would be improved if a common standard existed for labeling hippocampal subfields and parahippocampal subregions. Currently, research groups label different subsets of structures and use different rules, landmarks, and cues to define their anatomical extents. This paper characterizes, both qualitatively and quantitatively, the variability in the existing manual segmentation protocols for labeling hippocampal and parahippocampal substructures in MRI, with the goal of guiding subsequent work on developing a harmonized substructure segmentation protocol. Method: MRI scans of a single healthy adult human subject were acquired both at 3 T and 7 T. Representatives from 21 research groups applied their respective manual segmentation protocols to the MRI modalities of their choice. The resulting set of 21 segmentations was analyzed in a common anatomical space to quantify similarity and identify areas of agreement. Results: The differences between the 21 protocols include the region within which segmentation is performed, the set of anatomical labels used, and the extents of specific anatomical labels. The greatest overall disagreement among the protocols is at the CA1/subiculum boundary, and disagreement across all structures is greatest in the anterior portion of the hippocampal formation relative to the body and tail. Conclusions: The combined examination of the 21 protocols in the same dataset suggests possible strategies towards developing a harmonized subfield segmentation protocol and facilitates comparison between published studies. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：526 / 541

页数：16

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