RHEUMATOID ARTHRITIS Are ACPA-positive and ACPA-negative RA the same disease?

被引：71

作者：

Daha, Nina A. ^{[1
]}

Toes, Rene E. M. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Rheumatol, NL-2333 ZA Leiden, Netherlands

来源：

NATURE REVIEWS RHEUMATOLOGY | 2011年 / 7卷 / 04期

关键词：

ANTIBODIES; ASSOCIATION;

D O I：

10.1038/nrrheum.2011.28

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Seemingly contrasting genetic backgrounds in anti-citrullinated-protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) support the notion that these are in fact two distinct disease subsets, with different underlying pathogenesis, that might need tailored treatment strategies.

引用

页码：203 / 204

页数：2

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