AVAILABLE THERAPIES AND CURRENT MANAGEMENT OF FIBROMYALGIA: FOCUSING ON PHARMACOLOGICAL AGENTS

被引：14

作者：

Han, C. ^{[1
]}

Lee, S-J. ^{[2
]}

Lee, S-Y. ^{[2
]}

Seo, H-J. ^{[2
]}

Wang, S-M. ^{[2
]}

Park, M-H. ^{[3
]}

Patkar, A. A. ^{[4
]}

Koh, J. ^{[5
]}

Masand, P. S. ^{[4
]}

Pae, C-U. ^{[2
]}

机构：

[1] Korea Univ, Dept Psychiat, Seoul, South Korea

[2] Catholic Univ Korea, Coll Med, Dept Psychiat, Seoul, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Neuropsychiat, Div Child & Adolescent Psychiat, Seoul, South Korea

[4] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA

[5] Catholic Univ Korea, Coll Med, Dept Urol, Seoul, South Korea

来源：

DRUGS OF TODAY | 2011年 / 47卷 / 07期

基金：

美国国家卫生研究院;

关键词：

PLACEBO-CONTROLLED TRIAL; MAJOR DEPRESSIVE DISORDER; DOUBLE-BLIND; CLINICAL-TRIAL; POOLED ANALYSIS; DIABETIC POLYNEUROPATHY; S-ADENOSYLMETHIONINE; COMPARATIVE EFFICACY; MULTICENTER TRIAL; PAIN THRESHOLD;

D O I：

10.1358/dot.2011.47.7.1603503

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Fibromyalgia (FM) is a chronic medical condition characterized by physical, psychiatric and psychological symptoms. Widespread pain, fatigue, sleep disturbances, heightened sensitivity, morning stiffness, decreased volition, depressed mood and a history of early abuse are frequently reported by patients with FM. Treatment of fibromyalgia is multidisciplinary, with an emphasis on active patient participation, medications, cognitive-behavioral therapy and physical modalities. No single medication has yet been found to sufficiently control all the symptoms of FM; currently available medication classes include antidepressants, nonsteroidal anti-inflammatory drugs, opioids, sedatives, muscle relaxants, analgesics, hypnotic agents and anticonvulsants. Hence, treatment for patients with FM, including pharmacological and non-pharmacological approaches, should be individualized based on each patient's clinical history, target symptoms and functional impairments. Although nonpharmacological modalities are also frequently used, recent research has focused on identifying more effective pharmacological treatments, particularly antidepressants and anticonvulsants. Furthermore, several new pharmacological agents have been now officially approved for the treatment of patients with FM. Thus, the purpose of this review is to help healthcare professionals make informed decisions about the appropriate use of a number of pharmacological treatments for patients with FM.

引用

页码：539 / 557

页数：19

共 114 条

[1]

Ackenheil M, 1998, Z RHEUMATOL, V57, P5

[2] Citalopram in patients with fibromyalgia - a randomized, double blind, placebo-controlled study [J].