WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines

被引：95

作者：

Sung, Jee Young ^{[1
]}

Engmann, Olivia ^{[1
]}

Teylan, Merilee A. ^{[1
]}

Nairn, Angus C. ^{[1
,2
]}

Greengard, Paul ^{[1
]}

Kim, Yong ^{[1
]}

机构：

[1] Rockefeller Univ, Mol & Cellular Neurosci Lab, New York, NY 10065 USA

[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06508 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 08期

关键词：

cdk5; filopodia; depolarization; phosphorylation; NMDA receptor;

D O I：

10.1073/pnas.0712180105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mitochondrial fission and trafficking to dendritic protrusions have been implicated in dendritic spine development. Here, we show that Wiskott-Aldrich syndrome protein (WASP)-family verprolin homologous protein 1 (WAVE1) controls depolarization-induced mitochondrial movement into dendritic spines and filopodia and regulates spine morphogenesis. Depolarization-induced degradation of the p35 regulatory subunit of cyclin-dependent kinase 5 (Cdk5), with the resultant decreased inhibitory phosphorylation on WAVE1, depend on NMDA receptor activation. Thus, WAVE1 dephosphorylation and activation are likely associated with mitochondrial redistribution and spine morphogenesis.

引用

页码：3112 / 3116

页数：5

共 52 条

[1] QUANTITATIVE ULTRASTRUCTURAL-CHANGES IN RAT CORTICAL SYNAPSES DURING EARLY-ADULTHOOD AND LATE-ADULTHOOD [J].

ADAMS, I ;

JONES, DG .

BRAIN RESEARCH, 1982, 239 (02) :349-363

[2] The B"/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A [J].

Ahn, Jung-Hyuck ;

Sung, Jee Young ;

McAvoy, Thomas ;

Nishi, Akinori ;

Janssens, Veerle ;

Goris, Jozef ;

Greengard, Paul ;

Nairn, Angus C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (23) :9876-9881

[3] Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56δ subunit [J].

Ahn, Jung-Hyuck ;

McAvoy, Thomas ;

Rakhilin, Sergey V. ;

Nishi, Akinori ;

Greengard, Paul ;

Nairn, Angus C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (08) :2979-2984

[4]

Blaustein M P, 1978, Ann N Y Acad Sci, V307, P195, DOI 10.1111/j.1749-6632.1978.tb41943.x

[5] ORGANIZATION OF MITOCHONDRIA IN OLFACTORY-BULB GRANULE CELL DENDRITIC SPINES [J].

CAMERON, HA ;

KALISZEWSKI, CK ;

GREER, CA .

SYNAPSE, 1991, 8 (02) :107-118

[6] Nerve growth factor signaling regulates motility and docking of axonal mitochondria [J].

Chada, SR ;

Hollenbeck, PJ .

CURRENT BIOLOGY, 2004, 14 (14) :1272-1276

[7] Mitochondrial movement and positioning in axons: the role of growth factor signaling [J].

Chada, SR ;

Hollenbeck, PJ .

JOURNAL OF EXPERIMENTAL BIOLOGY, 2003, 206 (12) :1985-1992

[8] Mitochondria: Dynamic organelles in disease, aging, and development [J].

Chan, David C. .

CELL, 2006, 125 (07) :1241-1252

[9] Mitochondrial trafficking to synapses in cultured primary cortical neurons [J].

Chang, Diane T. W. ;

Honick, Anthony S. ;

Reynolds, Ian J. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (26) :7035-7045

[10] Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development [J].

Chen, HC ;

Detmer, SA ;

Ewald, AJ ;

Griffin, EE ;

Fraser, SE ;

Chan, DC .

JOURNAL OF CELL BIOLOGY, 2003, 160 (02) :189-200

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