Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation

被引：127

作者：

Fiorito, Giovanni ^{[1
,2
]}

Polidoro, Silvia ^{[1
]}

Dugue, Pierre-Antoine ^{[3
,4
]}

Kivimaki, Mika ^{[5
]}

Ponzi, Erica ^{[6
]}

Matullo, Giuseppe ^{[1
,2
]}

Guarrera, Simonetta ^{[1
,2
]}

Assumma, Manuela B. ^{[1
,2
]}

Georgiadis, Panagiotis ^{[7
]}

Kyrtopoulos, Soterios A. ^{[7
]}

Krogh, Vittorio ^{[8
]}

Palli, Domenico ^{[9
]}

Panico, Salvatore ^{[10
]}

Sacerdote, Carlotta ^{[11
]}

Tumino, Rosario ^{[12
]}

Chadeau-Hyam, Marc ^{[13
]}

Stringhini, Silvia ^{[14
]}

Severi, Gianluca ^{[1
,15
]}

Hodge, Allison M. ^{[3
,4
]}

Giles, Graham G. ^{[3
,4
]}

Marioni, Riccardo ^{[16
]}

Linner, Richard Karlsson ^{[17
]}

O'Halloran, Aisling M. ^{[18
]}

Kenny, Rose A. ^{[18
]}

Layte, Richard ^{[18
]}

Baglietto, Laura ^{[19
]}

Robinson, Oliver ^{[13
]}

McCrory, Cathal ^{[18
]}

Milne, Roger L. ^{[3
,4
]}

Vineis, Paolo ^{[1
,13
]}

机构：

[1] IIGM, Via Nizza 52, I-10126 Turin, Italy

[2] Univ Turin, Dept Med Sci, Dogliotti 14, I-10126 Turin, Italy

[3] Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia

[4] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic 3010, Australia

[5] UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England

[6] Univ Zurich, Inst Evolutionary Biol & Environm Studies, Winterthurerstr 190, Zurich, Switzerland

[7] Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Leof Vasileos Konstantinou 48, Athens 11635, Greece

[8] Fdn IRCCS Ist Nazl Tumori, Via Venezian 1, I-20133 Milan, Italy

[9] Ist Studio Prevenz Oncol ISPO Toscana, Via Cosimo 2 Vecchio 2, I-50139 Florence, Italy

[10] Univ Naples Federico II, Dept Clin Med & Surg, Corso Umberto 1,40, I-80138 Naples, Italy

[11] Piedmont Reference Ctr Epidemiol & Canc Prevent C, Via Santena 7, I-10126 Turin, Italy

[12] ASP Ragusa, Civ MP Arezzo Hosp, Canc Registry & Histopathol Dept, Piazza Igea 1, I-97100 Ragusa, Italy

[13] Imperial Coll London, MRC PHE Ctr Environm & Hlth, St Marys Campus Paddington, London W2 1PG, England

[14] Univ Lausanne Hosp CHUV, Inst Social & Prevent Med, Rue Bugnon 46, CH-1011 Lausanne, Switzerland

[15] Gustave Roussy Inst, Ctr Res Epidemiol & Populat Hlth CESP, INSERM, U1018, 114 Rue Edouard Vaillant, F-94805 Villejuif, France

[16] Univ Edinburgh, Ctr Genom & Expt Med, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland

[17] Vrije Univ Amsterdam, NCA, CNCR, Dept Complex Trait Genet, Boelelaan 1085-1087, NL-1081 HV Amsterdam, Netherlands

[18] Trinity Coll Dublin, Dublin, Ireland

[19] Univ Pisa, Dept Clin & Expt Med, Lungarno Antonio Pacinotti 43, I-56126 Pisa, Italy

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

英国医学研究理事会; 欧盟地平线“2020”; 瑞士国家科学基金会;

关键词：

WEAR-AND-TEAR; MIDLIFE FINDINGS; CHILDHOOD EXPERIENCES; ALLOSTATIC LOAD; DISEASE RISK; POSITION; METAANALYSIS; SMOKING; IMPACTS; HEALTH;

D O I：

10.1038/s41598-017-16391-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (beta = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social

引用

页数：12

共 47 条

[41] Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study
Stringhini, Silvia
Batty, G. David
Bovet, Pascal
Shipley, Martin J.
Marmot, Michael G.
Kumari, Meena
Tabak, Adam G.
Kivimaeki, Mika
[J]. PLOS MEDICINE, 2013, 10 (07)
[42] Health Behaviours, Socioeconomic Status, and Mortality: Further Analyses of the British Whitehall II and the French GAZEL Prospective Cohorts
Stringhini, Silvia
Dugravot, Aline
Shipley, Martin
Goldberg, Marcel
Zins, Marie
Kivimaeki, Mika
Marmot, Michael
Sabia, Severine
Singh-Manoux, Archana
[J]. PLOS MEDICINE, 2011, 8 (02)
[43] Association of Socioeconomic Position With Health Behaviors and Mortality
Stringhini, Silvia
Sabia, Severine
Shipley, Martin
Brunner, Eric
Nabi, Hermann
Kivimaki, Mika
Singh-Manoux, Archana
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (12): : 1159 - 1166
[44] Early life socioeconomic factors and genomic DNA methylation in mid-life
Tehranifar, Parisa
Wu, Hui-Chen
Fan, Xiaozhou
Flom, Julie D.
Ferris, Jennifer S.
Cho, Yoon Hee
Gonzalez, Karina
Santella, Regina M.
Terry, Mary Beth
[J]. EPIGENETICS, 2013, 8 (01) : 23 - 27
[45] Missing value estimation methods for DNA microarrays
Troyanskaya, O
Cantor, M
Sherlock, G
Brown, P
Hastie, T
Tibshirani, R
Botstein, D
Altman, RB
[J]. BIOINFORMATICS, 2001, 17 (06) : 520 - 525
[46] Social environment is associated with gene regulatory variation in the rhesus macaque immune system
Tung, Jenny
Barreiro, Luis B.
Johnson, Zachary P.
Hansen, Kasper D.
Michopoulos, Vasiliki
Toufexis, Donna
Michelini, Katelyn
Wilson, Mark E.
Gilad, Yoav
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (17) : 6490 - 6495
[47] The Index of Relative Socio-economic Disadvantage: general population views on indicators used to determine area-based disadvantage
Walker, R
Hiller, JE
[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, 2005, 29 (05) : 442 - 447

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