Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation

被引：127

作者：

Fiorito, Giovanni ^{[1
,2
]}

Polidoro, Silvia ^{[1
]}

Dugue, Pierre-Antoine ^{[3
,4
]}

Kivimaki, Mika ^{[5
]}

Ponzi, Erica ^{[6
]}

Matullo, Giuseppe ^{[1
,2
]}

Guarrera, Simonetta ^{[1
,2
]}

Assumma, Manuela B. ^{[1
,2
]}

Georgiadis, Panagiotis ^{[7
]}

Kyrtopoulos, Soterios A. ^{[7
]}

Krogh, Vittorio ^{[8
]}

Palli, Domenico ^{[9
]}

Panico, Salvatore ^{[10
]}

Sacerdote, Carlotta ^{[11
]}

Tumino, Rosario ^{[12
]}

Chadeau-Hyam, Marc ^{[13
]}

Stringhini, Silvia ^{[14
]}

Severi, Gianluca ^{[1
,15
]}

Hodge, Allison M. ^{[3
,4
]}

Giles, Graham G. ^{[3
,4
]}

Marioni, Riccardo ^{[16
]}

Linner, Richard Karlsson ^{[17
]}

O'Halloran, Aisling M. ^{[18
]}

Kenny, Rose A. ^{[18
]}

Layte, Richard ^{[18
]}

Baglietto, Laura ^{[19
]}

Robinson, Oliver ^{[13
]}

McCrory, Cathal ^{[18
]}

Milne, Roger L. ^{[3
,4
]}

Vineis, Paolo ^{[1
,13
]}

机构：

[1] IIGM, Via Nizza 52, I-10126 Turin, Italy

[2] Univ Turin, Dept Med Sci, Dogliotti 14, I-10126 Turin, Italy

[3] Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia

[4] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic 3010, Australia

[5] UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England

[6] Univ Zurich, Inst Evolutionary Biol & Environm Studies, Winterthurerstr 190, Zurich, Switzerland

[7] Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Leof Vasileos Konstantinou 48, Athens 11635, Greece

[8] Fdn IRCCS Ist Nazl Tumori, Via Venezian 1, I-20133 Milan, Italy

[9] Ist Studio Prevenz Oncol ISPO Toscana, Via Cosimo 2 Vecchio 2, I-50139 Florence, Italy

[10] Univ Naples Federico II, Dept Clin Med & Surg, Corso Umberto 1,40, I-80138 Naples, Italy

[11] Piedmont Reference Ctr Epidemiol & Canc Prevent C, Via Santena 7, I-10126 Turin, Italy

[12] ASP Ragusa, Civ MP Arezzo Hosp, Canc Registry & Histopathol Dept, Piazza Igea 1, I-97100 Ragusa, Italy

[13] Imperial Coll London, MRC PHE Ctr Environm & Hlth, St Marys Campus Paddington, London W2 1PG, England

[14] Univ Lausanne Hosp CHUV, Inst Social & Prevent Med, Rue Bugnon 46, CH-1011 Lausanne, Switzerland

[15] Gustave Roussy Inst, Ctr Res Epidemiol & Populat Hlth CESP, INSERM, U1018, 114 Rue Edouard Vaillant, F-94805 Villejuif, France

[16] Univ Edinburgh, Ctr Genom & Expt Med, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland

[17] Vrije Univ Amsterdam, NCA, CNCR, Dept Complex Trait Genet, Boelelaan 1085-1087, NL-1081 HV Amsterdam, Netherlands

[18] Trinity Coll Dublin, Dublin, Ireland

[19] Univ Pisa, Dept Clin & Expt Med, Lungarno Antonio Pacinotti 43, I-56126 Pisa, Italy

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

英国医学研究理事会; 欧盟地平线“2020”; 瑞士国家科学基金会;

关键词：

WEAR-AND-TEAR; MIDLIFE FINDINGS; CHILDHOOD EXPERIENCES; ALLOSTATIC LOAD; DISEASE RISK; POSITION; METAANALYSIS; SMOKING; IMPACTS; HEALTH;

D O I：

10.1038/s41598-017-16391-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (beta = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social

引用

页数：12

共 47 条

[21] DNA methylation age of human tissues and cell types
Horvath, Steve
[J]. GENOME BIOLOGY, 2013, 14 (10):
[22] DNA methylation arrays as surrogate measures of cell mixture distribution
Houseman, Eugene Andres
Accomando, William P.
Koestler, Devin C.
Christensen, Brock C.
Marsit, Carmen J.
Nelson, Heather H.
Wiencke, John K.
Kelsey, Karl T.
[J]. BMC BIOINFORMATICS, 2012, 13
[23] DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Joubert, Bonnie R.
Felix, Janine F.
Yousefi, Paul
Bakulski, Kelly M.
Just, Allan C.
Breton, Carrie
Reese, Sarah E.
Markunas, Christina A.
Richmond, Rebecca C.
Xu, Cheng-Jian
Kupers, Leanne K.
Oh, Sam S.
Hoyo, Cathrine
Gruzieva, Olena
Soderhal, Cilla
Salas, Lucas A.
Baiz, Nour
Zhang, Hongmei
Lepeule, Johanna
Ruiz, Carlos
Ligthart, Symen
Wang, Tianyuan
Taylor, Jack A.
Duijts, Liesbeth
Sharp, Gemma C.
Jankipersadsing, Soesma A.
Nilsen, Roy M.
Vaez, Ahmad
Fallin, M. Daniele
Hu, Donglei
Litonjua, Augusto A.
Fuemmeler, Bernard F.
Huen, Karen
Kere, Juha
Kull, Inger
Munthe-Kaas, Monica Cheng
Gehring, Ulrike
Bustamante, Mariona
Saurel-Coubizolles, Marie Jose
Quraishi, Bilal M.
Ren, Jie
Tost, Jorg
Gonzalez, Juan R.
Peters, Marjolein J.
Haberg, Siri E.
Xu, Zongli
van Meurs, Joyce B.
Gaunt, Tom R.
Kerkhof, Marjan
Corpeleijn, Eva
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2016, 98 (04) : 680 - 696
[24] Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns
Joubert, Bonnie R.
den Dekker, Herman T.
Felix, Janine F.
Bohlin, Jon
Ligthart, Symen
Beckett, Emma
Tiemeier, Henning
van Meurs, Joyce B.
Uitterlinden, Andre G.
Hofman, Albert
Haberg, Siri E.
Reese, Sarah E.
Peters, Marjolein J.
Andreassen, Bettina Kulle
Steegers, Eric A. P.
Nilsen, Roy M.
Vollset, Stein E.
Midttun, Oivind
Ueland, Per M.
Franco, Oscar H.
Dehghan, Abbas
de Jongste, Johan C.
Wu, Michael C.
Wang, Tianyuan
Peddada, Shyamal D.
Jaddoe, Vincent W. V.
Nystad, Wenche
Duijts, Liesbeth
London, Stephanie J.
[J]. NATURE COMMUNICATIONS, 2016, 7
[25] Adverse childhood experiences and premature all-cause mortality
Kelly-Irving, Michelle
Lepage, Benoit
Dedieu, Dominique
Bartley, Mel
Blane, David
Grosclaude, Pascale
Lang, Thierry
Delpierre, Cyrille
[J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2013, 28 (09) : 721 - 734
[26] Cigarette Smoking and Inflammation: Cellular and Molecular Mechanisms
Lee, J.
Taneja, V.
Vassallo, R.
[J]. JOURNAL OF DENTAL RESEARCH, 2012, 91 (02) : 142 - 149
[27] Equivalence of the mediation, confounding and suppression effect
MacKinnon D.P.
Krull J.L.
Lockwood C.M.
[J]. Prevention Science, 2000, 1 (4) : 173 - 181
[28] Mediation analysis
MacKinnon, David P.
Fairchild, Amanda J.
Fritz, Matthew S.
[J]. ANNUAL REVIEW OF PSYCHOLOGY, 2007, 58 : 593 - 614
[29] Marmot Michael., 2004, STATUS SYNDROME YOUR
[30] Factor Structure Underlying Components of Allostatic Load
McCaffery, Jeanne M.
Marsland, Anna L.
Strohacker, Kelley
Muldoon, Matthew F.
Manuck, Stephen B.
[J]. PLOS ONE, 2012, 7 (10):

← 1 2 3 4 5 →