Induction of broad cross-subtype-specific HIV-1 immune responses by a novel multivalent HIV-1 peptide vaccine in cynomolgus macaques

被引：27

作者：

Azizi, Ali ^{[1
,2
,3
]}

Anderson, David E. ^{[1
,6
]}

Torres, Jose V. ^{[1
,4
]}

Ogrel, Andrei ^{[1
]}

Ghorbani, Masoud ^{[1
]}

Soare, Catalina ^{[1
,2
,3
]}

Sandstrom, Paul ^{[5
]}

Fournier, Jocelyne ^{[5
]}

Diaz-Mitoma, Francisco ^{[1
,2
,3
]}

机构：

[1] Variat Biotechnol, Ottawa, ON, Canada

[2] Univ Ottawa, Dept Pathol & Lab Med, Div Virol & Mol Immunol, Ottawa, ON K1N 6N5, Canada

[3] Childrens Hosp Eastern Ontario, Div Virol & Mol Immunol, Res Inst, Ottawa, ON K1H 8L1, Canada

[4] Univ Calif Davis, Davis Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA

[5] Publ Hlth Agcy Canada, Div HIV, Ottawa, ON, Canada

[6] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 180卷 / 04期

关键词：

D O I：

10.4049/jimmunol.180.4.2174

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One of the major obstacles in the design of an effective vaccine against HIV-1 is its antigenic variation, which results in viral escape from the immune system. Through a bioinformatics approach, we developed an innovative multivalent HIV-1. vaccine comprised of a pool of 176 lipidated and nonlipidated peptides representing variable regions of Env and Gag proteins. The potency and breadth of the candidate vaccine against a panel of HIV-1 subtypes was evaluated in nonhuman primate (cynomolgus macaques) and humanized mouse (HLA-A2.1) models. The results demonstrate strong immunogenicity with both breadth (humoral and cellular immunity) and depth (immune recognition of widely divergent viral sequences) against heterologous HIV-1 subtypes A-F.

引用

页码：2174 / 2186

页数：13

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