Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives

被引：231

作者：

Rashad, Aymn E. ^{[1
]}

Hegab, Mohamed I. ^{[1
]}

Abdel-Megeid, Randa E. ^{[1
]}

Micky, Jehan A. ^{[2
]}

Abdel-Megeid, Farouk M. E. ^{[1
]}

机构：

[1] Natl Res Ctr, Photochem Dept, Cairo, Egypt

[2] Al Azhar Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 15期

关键词：

pyrazole; pyrazolo[3,4-d] pyrimidine; S- and N-nucleosides; antiviral activity;

D O I：

10.1016/j.bmc.2008.06.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some novel substituted pyrazole and pyrazolo[3,4-d] pyrimidine derivatives 2, 4, 8, and 9 were synthesized. Also, some acyclic S-nucleosides of pyrazolo[3,4-d] pyrimidine derivatives 10 -13 were prepared via reaction of pyrazolo[3,4-d] pyrimidine-4(3H)-thione derivative 9 with some acyclic sugars. Moreover, the N-nucleoside derivative 14 was prepared via reaction of compound 8 with glucosamine hydrochloride. The antiviral evaluation of some selected new products showed that they have promising antiviral activity against hepatitis-A virus (HAV) and herpes simplex virus type-1 (HSV-1). (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：7102 / 7106

页数：5

共 30 条

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[2]

Alfred A., 1997, Ger. Offen. DE Patent, Patent No. [19,751,943, 19751943]

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