Impaired myocardial autophagy linked to energy metabolism disorders

被引：21
|
作者：
Li, Zi-Lun [1 ,2 ]
Lerman, Lilach O. [1 ,3 ]
机构：
[1] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Div Vasc Surg, Guangzhou 510275, Guangdong, Peoples R China
[3] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA
来源：
AUTOPHAGY | 2012年 / 8卷 / 06期
关键词：
MTOR; autophagy; energy metabolism; mitochondrial biogenesis; apoptosis; metabolic syndrome;
D O I：
10.4161/auto.20285
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Autophagy represents an evolutionarily conserved catabolic mechanism that promotes cell survival by releasing energy substrates via degradation of cellular constituents and by eliminating defective organelles under conditions of stress, such as starvation and hypoxia. The link between enhanced autophagy and nutrient deprivation has been well established. For example, chronic myocardial ischemia, a condition of insufficient oxygen and nutrition, activates autophagy to degrade and recycle damaged cellular structures, thereby ameliorating cardiomyocyte injury.
引用
收藏
页码：992 / 994
页数：3
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