NO synthase and cardiovascular gene therapy

被引：0
|
作者：
von der Leyen, HE [1 ]
机构：
[1] Cardion AG, D-40699 Erkrath, Germany
来源：
ZEITSCHRIFT FUR KARDIOLOGIE | 2001年 / 90卷 / 11期
关键词：
nitric oxide; NOS; gene therapy; review;
D O I：
10.1007/s003920170079
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Molecular biology research of vascular remodeling paved the way to novel therapeutic approaches in experimental cardiology. Using gene transfer methods in various animal models, it has been shown that overexpression of nitric oxide synthase (NOS) can inhibit neointimal lesion proliferation. This review summarizes pivotal data regarding NO synthase gene manipulation in the cardiovascular system which enabled transition of this experimental approach from the bench to the clinical arena.
引用
收藏
页码：807 / 812
页数：6
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