Kinetics study of KPC-3, a plasmid-encoded class a carbapenem-hydrolyzing β-lactamase

被引：60

作者：

Alba, J

Ishii, Y

Thomson, K

Moland, ES

Yamaguchi, K

机构：

[1] Toho Univ, Sch Med, Dept Microbiol & Infect Dis, Ota Ku, Tokyo 1438540, Japan

[2] Creighton Univ, Sch Med, Ctr Res Anti Infect & Biotechnol, Dept Med Microbiol & Immunol, Omaha, NE 68178 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 11期

关键词：

D O I：

10.1128/AAC.49.11.4760-4762.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The kinetic activity of KPC-3, a plasmid-encoded class A carbapenemase, was studied. It hydrolyzed penicillins, cephalosporins, carbapenems, and even sulbactam. The best substrate was cephalothin (k(cat)/(K)m = 3.48 mu M-1 s(-1)). The efficiency of the enzyme was similar for imipenem and meropenem (k(cat)/K-m, 1.4 and 1.94 mu M-1 s(-1), respectively).

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页码：4760 / 4762

页数：3

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