Alcoholism and Cellular Vulnerability in Different Brain Regions

被引：11
作者：
Skuja, Sandra [1 ]
Groma, Valerija [1 ]
Smane, Liene [1 ]
机构：
[1] Riga Stradins Univ, Inst Anat & Anthropol, Lab Electron Microscopy, LV-1010 Riga, Latvia
来源：
ULTRASTRUCTURAL PATHOLOGY | 2012年 / 36卷 / 01期
关键词：
Alcohol; electron microscopy; myelin sheath; prefrontal cortex; striatum; substantia nigra; synapses; MYELINATED NERVE-FIBERS; WHITE-MATTER; CEREBRAL-CORTEX; ETHANOL; ASTROCYTES; DOPAMINE; CELLS; DRUG; CONSUMPTION; ADDICTION;
D O I：
10.3109/01913123.2011.629770
中图分类号：
TH742 [显微镜];
学科分类号：
摘要：
Alcohol-induced damage causes dysfunction of selected brain regions. Multidisciplinary studies have provided an extensive description of changes observed in neurons and glia following alcohol consumption. In this study the authors have elucidated preferential cellular vulnerability in three different brain regions. Autopsy material of the prefrontal cortex, striatum, and substantia nigra obtained from the brain tissue of alcoholic subjects was used in this study. We found that dendritic tree and astroglial damage is irreversible, while neuronal somata and most axons do not display irreversible changes.
引用
收藏
页码：40 / 47
页数：8
相关论文
共 53 条
  • [1] Ethanol-induced modulation of synaptic output from the dorsolateral striatum in rat is regulated by cholinergic interneurons
    Adermark, Louise
    Clarke, Rhona B. C.
    Soderpalm, Bo
    Ericson, Mia
    [J]. NEUROCHEMISTRY INTERNATIONAL, 2011, 58 (06) : 693 - 699
  • [2] Implications for glycine receptors and astrocytes in ethanol-induced elevation of dopamine levels in the nucleus accumbens
    Adermark, Louise
    Clarke, Rhona B. C.
    Olsson, Torsten
    Hansson, Elisabeth
    Soderpalm, Bo
    Ericson, Mia
    [J]. ADDICTION BIOLOGY, 2011, 16 (01) : 43 - 54
  • [3] Aschner M, 2002, BRAIN PATHOL, V12, P475
  • [4] The role of the dorsal striatum in reward and decision-making
    Balleine, Bernard W.
    Delgado, Mauricio R.
    Hikosaka, Okihide
    [J]. JOURNAL OF NEUROSCIENCE, 2007, 27 (31) : 8161 - 8165
  • [5] Neuron-astrocyte interactions: Partnership for normal function and disease in the central nervous system
    Benarroch, EE
    [J]. MAYO CLINIC PROCEEDINGS, 2005, 80 (10) : 1326 - 1338
  • [6] Ethanol Affects Striatal Interneurons Directly and Projection Neurons Through a Reduction in Cholinergic Tone
    Blomeley, Craig P.
    Cains, Sarah
    Smith, Richard
    Bracci, Enrico
    [J]. NEUROPSYCHOPHARMACOLOGY, 2011, 36 (05) : 1033 - 1046
  • [7] Age Changes in Myelinated Nerve Fibers of the Cingulate Bundle and Corpus Callosum in the Rhesus Monkey
    Bowley, Michael P.
    Cabral, Howard
    Rosene, Douglas L.
    Peters, Alan
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2010, 518 (15) : 3046 - 3064
  • [8] Davis KM, 2001, J BIOMED SCI, V8, P7, DOI 10.1007/BF02255966
  • [9] No changes in neocortical cell volumes or glial cell numbers in chronic alcoholic subjects compared to control subjects
    Fabricius, Katrine
    Pakkenberg, Henning
    Pakkenberg, Bente
    [J]. ALCOHOL AND ALCOHOLISM, 2007, 42 (05): : 400 - 406
  • [10] Cortical gray matter loss in treatment-naive alcohol dependent individuals
    Fein, G
    Di Sclafani, V
    Cardenas, VA
    Goldmann, H
    Tolou-Shams, M
    Meyerhoff, DJ
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2002, 26 (04) : 558 - 564
123456