Lung imaging - Two dimensional gamma scintigraphy, SPECT, CT and PET

被引:51
作者
Conway, Joy [1 ,2 ]
机构
[1] Univ Southampton, Southampton Gen Hosp, Fac Hlth Sci, Southampton, Hants, England
[2] Southampton Gen Hosp, Southampton NIHR Resp Biomed Res Unit, Southampton SO9 4XY, Hants, England
关键词
Gamma scintigraphy; SPECT; CT; HRCT; PET; Lung imaging; Drug deposition; Lung anatomy; OBSTRUCTIVE PULMONARY-DISEASE; POSITRON-EMISSION-TOMOGRAPHY; METERED-DOSE INHALER; LONG-TERM CLEARANCE; CYSTIC-FIBROSIS; DRUG-DELIVERY; DRY POWDER; AEROSOL DEPOSITION; HEALTHY-VOLUNTEERS; PARTICLE-SIZE;
D O I
10.1016/j.addr.2012.01.013
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This review will cover the principles of imaging the deposition of inhaled drugs and some of the state-of-the art imaging techniques being used today. Aerosol deposition can be imaged and quantified by the addition of a radiolabel to the aerosol formulation. The subsequent imaging of the inhaled deposition pattern can be acquired by different imaging techniques. Specifically, this review will focus on the use of two-dimensional planar, gamma scintigraphy, SPECT, CT and PET. This review will look at how these imaging techniques are used to investigate the mechanisms of drug delivery in the lung and how the lung anatomy and physiology have the potential to alter therapeutic outcomes. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:357 / 368
页数:12
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