Novel 1, 2, 3-triazole-linked norcantharidin analogues: Synthesis and evaluation of growth inhibition in a panel of selected tumor-cell lines

被引：8

作者：

Deng, Liping ^{[1
,2
]}

Yang, Bo ^{[1
]}

He, Qiaojun ^{[1
]}

Hu, Yongzhou ^{[1
]}

机构：

[1] Zhejiang Univ, ZJU ENS Joint Lab Med Chem, Sch Pharmaceut Sci, Hangzhou 310058, Peoples R China

[2] Shaoxing Univ, Dept Pharmacol, Inst Chem & Chem Engn, Shaoxing 312000, Peoples R China

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2008年 / 5卷 / 03期

关键词：

1; 2; 3-triazole-linked; cantharidin; norcantharidin analogues; cycloaddition; tumor cell lines; growth inhibition;

D O I：

10.2174/157018008784083992

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twenty-one 1, 2, 3-triazole-linked norcantharidin analogues have been synthesized by the efficient [3+2]1, 3-dipolar cycloaddition reaction of norcantharidin derivatives with three organic azides. All analogues have been screened for their antiproliferative activity against a panel of tumor cell lines: KB, SMMC-7721, SGC7901, ECA109, HO8910 and K562. Compound 8e showed potency for the treatment of hepatoma, with GI(50) value (19.0 +/- 0.2 mu M) to SMMC-7721 cell line comparable to that of cantharidin (GI(50) value = 33.2 +/- 0.3 mu M).

引用

页码：225 / 231

页数：7

共 22 条

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