Steroids from the aerial parts of Leonurus japonicus

被引：22
作者：
Zhou, Qin-mei [1 ,2 ]
Peng, Cheng [1 ,2 ]
Yang, Huai [1 ,2 ]
Liu, Lu-si [1 ,2 ]
Yang, Yu-ting [1 ,2 ]
Xie, Xiao-fang [1 ,2 ]
Guo, Li [1 ,2 ]
Liu, Zhao-hua [3 ]
Xiong, Liang [1 ,2 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Peoples R China
[3] Chengdu 1 Pharmaceut Co Ltd, Chengdu 610031, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2015年 / 12卷
基金：
中国博士后科学基金;
关键词：
Leonurus japonicus; Steroids; Single crystal X-ray crystallographic analysis; Anti-platelet aggregative activity; LABDANE DITERPENES; ACID-ESTERS; HOUTT; HETEROPHYLLUS; CONSTITUENTS; DERIVATIVES; LEAVES; FRUITS; PLANTS;
D O I：
10.1016/j.phytol.2015.04.027
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new steroids, (24S)-stigmast-4,28-diene-24-ol-3-one (1) and mono-beta-sitosteryl azelate (2), along with ten known analogues (3-12), were isolated from the ethanolic extract of Leonurus japonicus Houtt. Their structures were elucidated by spectroscopic and chemical methods. The absolute configuration of 1 was confirmed by single crystal X-ray crystallographic analysis using anomalous scattering of Cu K alpha radiation. Compounds 3,4, and 9 showed significant inhibitory activities against ADP-induced platelet aggregation, while compound 1 had a weak cytotoxic activity against acute myeloid leukemia cell line MV4-11. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：287 / 290
页数：4
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