Steroids from the aerial parts of Leonurus japonicus

被引：22

作者：

Zhou, Qin-mei ^{[1
,2
]}

Peng, Cheng ^{[1
,2
]}

Yang, Huai ^{[1
,2
]}

Liu, Lu-si ^{[1
,2
]}

Yang, Yu-ting ^{[1
,2
]}

Xie, Xiao-fang ^{[1
,2
]}

Guo, Li ^{[1
,2
]}

Liu, Zhao-hua ^{[3
]}

Xiong, Liang ^{[1
,2
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Peoples R China

[3] Chengdu 1 Pharmaceut Co Ltd, Chengdu 610031, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2015年 / 12卷

基金：

中国博士后科学基金;

关键词：

Leonurus japonicus; Steroids; Single crystal X-ray crystallographic analysis; Anti-platelet aggregative activity; LABDANE DITERPENES; ACID-ESTERS; HOUTT; HETEROPHYLLUS; CONSTITUENTS; DERIVATIVES; LEAVES; FRUITS; PLANTS;

D O I：

10.1016/j.phytol.2015.04.027

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new steroids, (24S)-stigmast-4,28-diene-24-ol-3-one (1) and mono-beta-sitosteryl azelate (2), along with ten known analogues (3-12), were isolated from the ethanolic extract of Leonurus japonicus Houtt. Their structures were elucidated by spectroscopic and chemical methods. The absolute configuration of 1 was confirmed by single crystal X-ray crystallographic analysis using anomalous scattering of Cu K alpha radiation. Compounds 3,4, and 9 showed significant inhibitory activities against ADP-induced platelet aggregation, while compound 1 had a weak cytotoxic activity against acute myeloid leukemia cell line MV4-11. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：287 / 290

页数：4

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