The Uncommon Combination of Common Variable Immunodeficiency, Macrophage Activation Syndrome, and Cytomegalovirus Retinitis

被引：16

作者：

Aghamohammadi, Asghar ^{[1
]}

Abolhassani, Hassan ^{[1
]}

Hirbod-Mobarakeh, Armin ^{[1
]}

Ghassemi, Fariba ^{[2
]}

Shahinpour, Shervin ^{[1
]}

Behniafard, Nasrin ^{[1
]}

Naghibzadeh, Ghazal ^{[1
]}

Imanzadeh, Amir ^{[1
]}

Rezaei, Nima ^{[1
,3
,4
]}

机构：

[1] Childrens Med Ctr, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Tehran, Iran

[2] Farabi Hosp, Eye Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Sch Med, Mol Immunol Res Ctr, Tehran, Iran

[4] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

来源：

VIRAL IMMUNOLOGY | 2012年 / 25卷 / 02期

关键词：

AUTOIMMUNE MANIFESTATIONS; IMMUNOCOMPETENT PATIENTS; CLINICAL PHENOTYPES; INFECTION; CHILDREN; DEFICIENCY; MANAGEMENT; DISORDERS; UPDATE; ADULTS;

D O I：

10.1089/vim.2011.0060

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Common variable immunodeficiency (CVID) is a heterogeneous group of disorders with varied immunologic phenotypes and clinical manifestations. Patients with CVID are mainly characterized by decreased serum immunoglobulin levels, and increased susceptibility to recurrent bacterial infections, autoimmune disorders, and malignancies. Here we present a CVID patient who has developed a clinical polyclonal lymphocytic infiltration phenotype associated with severe and irreversible pancytopenia with unknown etiology. Progressive unilateral loss of vision and cytomegalovirus retinitis indicated the cause of patient's pancytopenia.

引用

页码：161 / 165

页数：5

共 37 条

[1]

Abolhassani H, 2011, J INVEST ALLERG CLIN, V21, P454

[2] Lymphoma of mucosa-associated lymphoid tissue in common variable immunodeficiency [J].

Aghamohammadi, A ;

Parvaneh, N ;

Tirgari, F ;

Mahjoob, F ;

Movahedi, M ;

Gharagozlou, M ;

Mansouri, M ;

Kouhi, A ;

Rezaei, N ;

Webster, D .

LEUKEMIA & LYMPHOMA, 2006, 47 (02) :343-346

[3] Clinical and immunological features of 65 Iranian patients with common variable immunodeficiency [J].

Aghamohammadi, A ;

Farhoudi, A ;

Moin, M ;

Rezaei, N ;

Kouhi, A ;

Pourpak, Z ;

Yaseri, N ;

Movahedi, M ;

Gharagozlou, M ;

Zandieh, F ;

Yazadni, F ;

Arshi, S ;

MohammadZadeh, I ;

Ghazi, BM ;

Mahmoudi, M ;

Tahaei, S ;

Isaeian, A .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2005, 12 (07) :825-832

[4]

Aghamohammadi A, 2010, J INVEST ALLERG CLIN, V20, P372

[5] Comparison of pulmonary diseases in common variable immunodeficiency and X-linked agammaglobulinaemia [J].

Aghamohammadi, Asghar ;

Allahverdi, Abdolreza ;

Abolhassani, Hassan ;

Moazzami, Kasra ;

Alizadeh, Hooman ;

Gharagozlou, Mohammad ;

Kalantari, Najmoddin ;

Sajedi, Vahid ;

Shafiei, Alireza ;

Parvaneh, Nima ;

Mohammadpour, Masoud ;

Karimi, Nasser ;

Sadaghiani, Mohammad Salehi ;

Rezaei, Nima .

RESPIROLOGY, 2010, 15 (02) :289-295

[6] Common variable immunodeficiency: a heterogeneous group needs further subclassification [J].

Aghamohammadi, Asghar ;

Parvaneh, Nima ;

Rezaei, Nima .

EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2009, 5 (06) :629-631

[7] Posterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome [J].

Banker, Alay S. .

INDIAN JOURNAL OF OPHTHALMOLOGY, 2008, 56 (05) :377-383

[8] Common variable immunodeficiency disorders: division into distinct clinical phenotypes [J].

Chapel, Helen ;

Lucas, Mary ;

Lee, Martin ;

Bjorkander, Janne ;

Webster, David ;

Grimbacher, Bodo ;

Fieschi, Claire ;

Thon, Vojtech ;

Abedi, Mohammad R. ;

Hammarstrom, Lennart .

BLOOD, 2008, 112 (02) :277-286

[9] Update in understanding common variable immunodeficiency disorders (CVIDs) and the management of patients with these conditions [J].

Chapel, Helen ;

Cunningham-Rundles, Charlotte .

BRITISH JOURNAL OF HAEMATOLOGY, 2009, 145 (06) :709-727

[10]

CLOSE P, 1990, MED PEDIATR ONCOL, V18, P119

← 1 2 3 4 →