Neurotransmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease

被引:47
作者
JimenezJimenez, FJ
Molina, JA
Vargas, C
Gomez, P
Navarro, JA
BenitoLeon, J
OrtiPareja, M
Gasalla, T
Cisneros, E
Arenas, J
机构
[1] HOSP UNIV PRINCIPE ASTURIAS, DEPT NEUROL, MADRID, SPAIN
[2] HOSP DOCE OCTUBRE, DEPT NEUROL, MADRID, SPAIN
[3] HOSP DOCE OCTUBRE, DEPT BIOCHEM, MADRID, SPAIN
关键词
Parkinson's disease; neurotransmitter amino acid; glutamate; aspartate; GABA; glycine; plasma; cerebrospinal fluid;
D O I
10.1016/0022-510X(96)00115-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We measured the CSF and plasma levels of glutamate, glutamine, aspartate (only in plasma), asparagine, glutamine, glycine and GABA in 31 patients with Parkinson's disease and in 45 matched controls. We used an ion-exchange chromatography method. When compared to controls, PD patients had similar CSF levels of glutamate, glutamine, asparagine, and glycine higher CSF GABA levels higher plasma levels of glutamine, asparagine, and glycine, and lower plasma levels of aspartate. The CSF levels of the amino acids measured were not correlated with the clinical features of PD. Our results that CSF GABA levels an not decreased in PD as previously suggested.
引用
收藏
页码:39 / 44
页数:6
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