Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis

被引：30

作者：

Valot, Gaelle ^{[1
]}

Garcia, Jose ^{[1
]}

Duplan, Vincent ^{[1
]}

Serba, Christelle ^{[1
]}

Barluenga, Sofia ^{[1
]}

Winssinger, Nicolas ^{[1
]}

机构：

[1] Univ Strasbourg, Strasbourg, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 22期

关键词：

cyclization; diversity-oriented synthesis; metathesis; natural products; transition metals; METAL-CATALYZED CYCLOISOMERIZATIONS; OLEFIN METATHESIS CATALYSTS; NF-KAPPA-B; ALLYLIC OXIDATION; ORGANIC-SYNTHESIS; TERT-BUTYLHYDROPEROXIDE; TERPENES; TARGET; ENYNES; CANCER;

D O I：

10.1002/anie.201201157

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Natural selection: An acyclic chain containing an ene-yne-ene motif, in analogy to farnesyl diphosphate, was cyclized to obtain six distinct scaffolds using different transition-metal catalysts (see scheme). Notably, the guaianolide framework was accessed through enynene metathesis enabling the synthesis of three natural products. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5391 / 5394

页数：4

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[1]

[Anonymous], 2011, Angew. Chem

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