One-pot sequence synthesis of azetidin-2-one using diethyl chlorophosphate

被引：26
作者：
Zarei, Maaroof [1 ]
机构：
[1] Hormozgan Univ, Coll Sci, Dept Chem, Bandar Abbas 71961, Iran
来源：
JOURNAL OF CHEMICAL RESEARCH | 2012年 / 02期
关键词：
beta-lactam; 2-azetidinone; Staudinger reaction; diethyl chlorophosphate; ketene; imine; MONOCYCLIC BETA-LACTAMS; 2-AZETIDINONE DERIVATIVES; ASYMMETRIC-SYNTHESIS; VILSMEIER REAGENT; ANTIBACTERIAL; RING; HETEROCYCLES; DESIGN; IMINES; SPIRO;
D O I：
10.3184/174751912X13282660033937
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and convenient synthesis of 2-azetidinone derivatives from the reaction of a pre-mixture of amines and aldehydes with carboxylic acids in the presence of diethyl chlorophosphate by [2+2] cycloaddition reaction is described. Separation and purification of imines as intermediates were not required. The methodology is convenient and good to excellent yields of products were obtained with simple purification.
引用
收藏
页码：118 / 120
页数：3
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