Cross-sectional associations of objectively-measured sleep characteristics with obesity and type 2 diabetes in the PREDIMED-Plus trial

被引：40

作者：

Rosique-Esteban, Nuria ^{[1
,2
]}

Papandreou, Christopher ^{[1
,2
]}

Romaguera, Dora ^{[2
,3
]}

Warnberg, Julia ^{[2
,4
]}

Corella, Dolores ^{[2
,5
]}

Angel Martinez-Gonzalez, Miguel ^{[2
,6
,7
]}

Diaz-Lopez, Andres ^{[1
,2
]}

Estruch, Ramon ^{[2
,8
]}

Vioque, Jesus ^{[9
,10
]}

Aros, Fernando ^{[2
,11
]}

Garcia-Rios, Antonio ^{[2
,12
]}

Bueno-Cavanillas, Aurora ^{[10
,13
]}

Vidal, Josep ^{[14
,15
,16
]}

Serra-Majem, Lluis ^{[2
,17
]}

Adlbi Sibai, Abdurrahman ^{[10
,18
,19
]}

Tinahones, Francisco J. ^{[2
,20
]}

Martinez, Alfredo ^{[2
,21
]}

Ordovas, Jose M. ^{[22
,23
]}

Tur, Josep A. ^{[2
,24
]}

Torrego Ellacuria, Macarena ^{[25
]}

Sanllorente, Albert ^{[2
,26
]}

Pinto, Xavier ^{[2
,27
]}

Buil-Cosiales, Pilar ^{[2
,6
,28
]}

Fernandez-Carrion, Rebeca ^{[2
,5
]}

Castaner, Olga ^{[2
,26
]}

Bullo, Monica ^{[1
,2
]}

Ruiz-Canela, Miguel ^{[2
,6
]}

Garcia-de la Hera, Manoli ^{[9
,10
]}

Perez-Farinos, Napoleon ^{[2
,29
]}

Javier Baron-Lopez, F. ^{[2
,29
]}

Colom, Antoni ^{[2
,3
]}

Abete, Itziar ^{[2
,21
]}

Ros, Emilio ^{[2
,8
]}

Salas-Salvado, Jordi ^{[1
,2
]}

机构：

[1] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Human Nutr Unit, St Joan Reus Hosp,IISPV, Reus, Spain

[2] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain

[3] Univ Hosp Son Espases, Inst Invest Sanitaria Illes Balears IdiSBa, Palma de Mallorca, Spain

[4] Univ Malaga, IBIMA, Dept Nursing, Malaga, Spain

[5] Univ Valencia, Dept Prevent Med, Valencia, Spain

[6] Univ Navarra, Inst Hlth Res DISNA, Dept Prevent Med & Publ Hlth, Pamplona, Spain

[7] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[8] Univ Barcelona, IDIBAPS August Pi i Sunyer Biomed Res Inst, Hosp Clin, Dept Internal Med, Barcelona, Spain

[9] Univ Miguel Hernandez, ISABIAL FISABIO, Nutr Epidemiol Unit, Alicante, Spain

[10] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[11] Univ Hosp Araba, Dept Cardiol, Vitoria, Spain

[12] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Dept Internal Med,Lipids & Atherosclerosis Unit, Cordoba, Spain

[13] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[14] Hosp Clin Barcelona, Endocrinol & Nutr Dept, Barcelona, Spain

[15] Inst Invest Biomed August Pi Sunyer, Barcelona, Spain

[16] CIBER Diabet Enfermedades & Metabol CIBERDEM, Madrid, Spain

[17] Univ Las Palmas Gran Canaria, CHUIMI, Canarian Hlth Serv, Prevent Med Serv,Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain

[18] Univ Leon, Inst Biomed IBIOMED, Leon, Spain

[19] Gerencia Atenc Primaria Area Salud Leon, Leon, Spain

[20] Malaga Univ, Virgen de la Victoria Hosp, Dept Endocrinol & Nutr, Malaga, Spain

[21] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain

[22] Madrid Inst Adv Studies IMDEA, Food Inst, Madrid, Spain

[23] Tufts Univ, Human Nutr Res Ctr Aging, JM USDA, Boston, MA 02111 USA

[24] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma de Mallorca, Spain

[25] Inst Invest Sanitaria San Carlos Idissc, Serv Endocrinol & Nutr, Madrid, Spain

[26] Hosp del Mar, Res Inst IMIM, Regicor Study Grp, Cardiovasc Risk & Nutr, Barcelona, Spain

[27] Hosp Univ Bellvitge, Hosp Llobregat, Bellvitge Biomed Res Inst IDIBELL, Dept Internal Med,Lipid Unit, Barcelona, Spain

[28] Serv Navarro Salud Osasunbidea, Atenc Primaria, Pamplona, Spain

[29] Univ Malaga, IBIMA, Dept Publ Hlth, Malaga, Spain

来源：

SLEEP | 2018年 / 41卷 / 12期

基金：

欧洲研究理事会;

关键词：

sleep duration; night-to-night sleep variability; accelerometry; adiposity; obesity; type; 2; diabetes; body composition; ABDOMINAL OBESITY; PHYSICAL-ACTIVITY; NATIONAL-HEALTH; WEIGHT CHANGE; DURATION; RISK; DISTURBANCES; VARIABILITY; ENDOCRINE; IMPACT;

D O I：

10.1093/sleep/zsy190

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study Objectives: To examine independent and combined associations of sleep duration and sleep variability with body composition, obesity and type 2 diabetes (T2D) in elders at high cardiovascular risk. Methods: Cross-sectional analysis of 1986 community-dwelling elders with overweight/obesity and metabolic syndrome from PREDIMEDPlus trial. Associations of accelerometry-derived sleep duration and sleep variability with body mass index (BMI), waist circumference (WC) and body composition were assessed fitting multivariable-adjusted linear regression models. Prevalence ratios (PR) and 95% confidence intervals (CI) for obesity and T2D were obtained using multivariable-adjusted Cox regression with constant time. "Bad sleepers" (age-specific non-recommended sleep duration plus sleep variability above the median) and "good sleepers" (age-specific recommended sleep duration plus sleep variability below the median) were characterized by combining sleep duration and sleep variability, and their associations with these outcomes were examined. Results: One hour/night increment in sleep duration was inversely associated with BMI (beta-0.38 kg/m(2) [95% CI -0.54, -0.23]), WC (beta-0.86 cm [95% CI -1.25, -0.47]), obesity (PR 0.96 [95% CI 0.93, 0.98]), T2D (PR 0.93 [95% CI 0.88, 0.98]) and other DXA-derived adiposity-related measurements (android fat and trunk fat, all p <.05). Each 1-hour increment in sleep variability was positively associated with T2D (PR 1.14 [95% CI 1.01, 1.28]). Compared with "good sleepers," "bad sleepers" were positively associated with obesity (PR 1.12 [95% CI 1.01, 1.24]) and T2D (PR 1.62 [95% CI 1.28, 2.06]). Conclusions: This study revealed cross-sectional associations of sleep duration with adiposity parameters and obesity. Sleep duration and sleep variability were associated with T2D. Considering simultaneously sleep duration and sleep variability could have additional value, particularly for T2D, as they may act synergistically.

引用

页数：10

共 38 条

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