Photoreversible Patterning of Biomolecules within Click-Based Hydrogels

被引：279

作者：

DeForest, Cole A. ^{[1
,2
]}

Anseth, Kristi S. ^{[1
,2
]}

机构：

[1] Univ Colorado, Boulder, CO 80309 USA

[2] Howard Hughes Med Inst, Boulder, CO 80309 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 08期

基金：

美国国家科学基金会;

关键词：

bioorganic chemistry; hydrogels; peptides; photochemistry; RGD peptides; 3D CELL-CULTURE; CHEMISTRY;

D O I：

10.1002/anie.201106463

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lighting the way: Biochemical cues have been reversibly patterned into hydrogels with full spatiotemporal control by using two photochemical reactions. The hydrogel is conjugated with a peptide by a thiol-ene photoaddition reaction that is initiated by visible light. Subsequent, selective photocleavage of an o-nitrobenzyl ether with UV light enables dynamic presentation of the peptide to cells with control in three dimensions. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1816 / 1819

页数：4

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