Photoreversible Patterning of Biomolecules within Click-Based Hydrogels

被引：274
作者：
DeForest, Cole A. [1 ,2 ]
Anseth, Kristi S. [1 ,2 ]
机构：
[1] Univ Colorado, Boulder, CO 80309 USA
[2] Howard Hughes Med Inst, Boulder, CO 80309 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 08期
基金：
美国国家科学基金会;
关键词：
bioorganic chemistry; hydrogels; peptides; photochemistry; RGD peptides; 3D CELL-CULTURE; CHEMISTRY;
D O I：
10.1002/anie.201106463
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Lighting the way: Biochemical cues have been reversibly patterned into hydrogels with full spatiotemporal control by using two photochemical reactions. The hydrogel is conjugated with a peptide by a thiol-ene photoaddition reaction that is initiated by visible light. Subsequent, selective photocleavage of an o-nitrobenzyl ether with UV light enables dynamic presentation of the peptide to cells with control in three dimensions. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1816 / 1819
页数：4
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