The Causes and Consequences of Polyploidy in Normal Development and Cancer

被引：322

作者：

Davoli, Teresa ^{[1
]}

de Lange, Titia ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Cell Biol & Genet, New York, NY 10065 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 | 2011年 / 27卷

关键词：

telomere; tetraploidy; aneuploidy; DNA-DAMAGE RESPONSE; ANAPHASE PROMOTING COMPLEX/CYCLOSOME; PANCREATIC DUCTAL CARCINOMA; ONCOGENE-INDUCED SENESCENCE; MESSENGER-RNA EXPRESSION; TROPHOBLAST GIANT-CELLS; POLYPOSIS-COLI PROTEIN; HUMAN BREAST CANCERS; SOFT-TISSUE SARCOMA; CHROMOSOMAL INSTABILITY;

D O I：

10.1146/annurev-cellbio-092910-154234

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although nearly all mammalian species are diploid, whole-genome duplications occur in select mammalian tissues as part of normal development. Such programmed polyploidization involves changes in the regulatory pathways that normally maintain the diploid state of the mammalian genome. Unscheduled whole-genome duplications, which lead primarily to tetraploid cells, also take place in a substantial fraction of human tumors and have been proposed to constitute an important step in the development of cancer aneuploidy. The origins of these polyploidization events and their consequences for tumor progression are explored in this review.

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页码：585 / 610

页数：26

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