An expeditious synthesis of 3′-α-carboxymethyl-2′-O-methyl ribonucleosides

被引：13

作者：

von Matt, P

Lochmann, T

Kesselring, R

Altmann, KH

机构：

[1] Novartis Pharmaceut, Summit, NJ 07901 USA

[2] Novartis Pharma AG, CH-4002 Basel, Switzerland

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(99)00147-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3'-alpha-Carboxymethyl-2'-O-methyl ribonucleosides, which are important building blocks for the construction of high affinity amide modified antisense oligonucleotides, have been synthesized from the corresponding 2'-O-methyl ribonucleosides via catalytic hydrogenation of their 3'-deoxy 3'-methoxycarbonyl-methylidene derivatives. Reduction of the olefinic double bond proceeds in good to excellent yields and with alpha/beta-product ratios > 9/1. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1873 / 1876

页数：4

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