Genetic Testing in Psychiatry: A Review of Attitudes and Beliefs
被引:41
作者:
Lawrence, Ryan E.
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机构:
Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USAColumbia Univ, Dept Psychiat, Med Ctr, New York, NY USA
Lawrence, Ryan E.
[1
]
Appelbaum, Paul S.
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机构:
Columbia Univ, Med Ctr, Ctr Res Eth Legal & Social Implicat Psychiat Neur, New York, NY 10027 USAColumbia Univ, Dept Psychiat, Med Ctr, New York, NY USA
Appelbaum, Paul S.
[2
]
机构:
[1] Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA
[2] Columbia Univ, Med Ctr, Ctr Res Eth Legal & Social Implicat Psychiat Neur, New York, NY 10027 USA
来源:
PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES
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2011年
/
74卷
/
04期
The advent of genetic testing for psychiatric conditions raises difficult questions about when and how the tests should be used. Development of policies regarding these issues may be informed in a variety of ways by the views of key stakeholders: patients, family members, healthcare professionals, and the general public. Here, we review empirical studies of attitudes towards genetic testing among these groups. Patients and family members show strong interest in diagnostic and predictive genetic testing, and to a considerable extent psychiatrists share their enthusiasm. Prenatal test utilization seems likely to depend both on parental views on abortion and the seriousness of the disorder. Parents show a surprising degree of interest in predictive testing of children, even when there are no preventive interventions available. Many persons report themselves ready to alter their lifestyles and plans for marriage and family in response to test results. Respondents also fear negative consequences, from discrimination to being unable to cope with knowledge of their "genetic fate." Empirical studies of beliefs about genetic testing suggest tests are likely to be embraced widely, but the studies have methodologic limitations, reducing the certainty of their conclusions, and indicating a need for further research with more representative samples.
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页码:315 / 331
页数:17
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[1]
Appelbaum Paul S, 2004, J Psychiatr Pract, V10, P343, DOI 10.1097/00131746-200411000-00002
机构:
Scripps Translat Sci Inst, La Jolla, CA 92037 USA
Scripps Hlth, La Jolla, CA USAScripps Translat Sci Inst, La Jolla, CA 92037 USA
Bloss, Cinnamon S.
;
Schork, Nicholas J.
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Scripps Translat Sci Inst, La Jolla, CA 92037 USA
Scripps Hlth, La Jolla, CA USA
Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USAScripps Translat Sci Inst, La Jolla, CA 92037 USA
Schork, Nicholas J.
;
Topol, Eric J.
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机构:
Scripps Translat Sci Inst, La Jolla, CA 92037 USA
Scripps Hlth, La Jolla, CA USA
Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
Scripps Clin, La Jolla, CA 92037 USAScripps Translat Sci Inst, La Jolla, CA 92037 USA
机构:
Univ Toronto, Dept Hlth Policy Management & Evaluat, Toronto, ON, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Bombard, Yvonne
;
Palin, JoAnne
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h-index: 0
机构:Univ British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Palin, JoAnne
;
Friedman, Jan M.
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h-index: 0
机构:
Childrens & Womens Hosp British Columbia, Vancouver, BC, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Friedman, Jan M.
;
Veenstra, Gerry
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Sociol, Vancouver, BC V5Z 1M9, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Veenstra, Gerry
;
Creighton, Susan
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机构:
Childrens & Womens Hosp British Columbia, Vancouver, BC, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Creighton, Susan
;
Paulsen, Jane S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA
Univ Iowa, Dept Psychol & Neurosci, Iowa City, IA 52242 USA
Univ Iowa, Dept Neurol, Iowa City, IA 52242 USAUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Paulsen, Jane S.
;
Bottorff, Joan L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia Okanagan, Fac Hlth & Social Dev, Kelowna, BC, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Bottorff, Joan L.
;
Hayden, Michael R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
机构:
Scripps Translat Sci Inst, La Jolla, CA 92037 USA
Scripps Hlth, La Jolla, CA USAScripps Translat Sci Inst, La Jolla, CA 92037 USA
Bloss, Cinnamon S.
;
Schork, Nicholas J.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Translat Sci Inst, La Jolla, CA 92037 USA
Scripps Hlth, La Jolla, CA USA
Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USAScripps Translat Sci Inst, La Jolla, CA 92037 USA
Schork, Nicholas J.
;
Topol, Eric J.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Translat Sci Inst, La Jolla, CA 92037 USA
Scripps Hlth, La Jolla, CA USA
Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
Scripps Clin, La Jolla, CA 92037 USAScripps Translat Sci Inst, La Jolla, CA 92037 USA
机构:
Univ Toronto, Dept Hlth Policy Management & Evaluat, Toronto, ON, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Bombard, Yvonne
;
Palin, JoAnne
论文数: 0引用数: 0
h-index: 0
机构:Univ British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Palin, JoAnne
;
Friedman, Jan M.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens & Womens Hosp British Columbia, Vancouver, BC, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Friedman, Jan M.
;
Veenstra, Gerry
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Sociol, Vancouver, BC V5Z 1M9, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Veenstra, Gerry
;
Creighton, Susan
论文数: 0引用数: 0
h-index: 0
机构:
Childrens & Womens Hosp British Columbia, Vancouver, BC, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Creighton, Susan
;
Paulsen, Jane S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA
Univ Iowa, Dept Psychol & Neurosci, Iowa City, IA 52242 USA
Univ Iowa, Dept Neurol, Iowa City, IA 52242 USAUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Paulsen, Jane S.
;
Bottorff, Joan L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia Okanagan, Fac Hlth & Social Dev, Kelowna, BC, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
Bottorff, Joan L.
;
Hayden, Michael R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, CanadaUniv British Columbia, Dept Med Genet, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada