Genetic Testing in Psychiatry: A Review of Attitudes and Beliefs

被引:41
作者
Lawrence, Ryan E. [1 ]
Appelbaum, Paul S. [2 ]
机构
[1] Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA
[2] Columbia Univ, Med Ctr, Ctr Res Eth Legal & Social Implicat Psychiat Neur, New York, NY 10027 USA
来源
PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES | 2011年 / 74卷 / 04期
关键词
BIPOLAR DISORDER; HEALTH-INSURANCE; GENOMIC ERA; RISK; FAMILIES; SCHIZOPHRENIA; SUSCEPTIBILITY; INTERVENTIONS; INFORMATION; INTENTIONS;
D O I
10.1521/psyc.2011.74.4.315
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The advent of genetic testing for psychiatric conditions raises difficult questions about when and how the tests should be used. Development of policies regarding these issues may be informed in a variety of ways by the views of key stakeholders: patients, family members, healthcare professionals, and the general public. Here, we review empirical studies of attitudes towards genetic testing among these groups. Patients and family members show strong interest in diagnostic and predictive genetic testing, and to a considerable extent psychiatrists share their enthusiasm. Prenatal test utilization seems likely to depend both on parental views on abortion and the seriousness of the disorder. Parents show a surprising degree of interest in predictive testing of children, even when there are no preventive interventions available. Many persons report themselves ready to alter their lifestyles and plans for marriage and family in response to test results. Respondents also fear negative consequences, from discrimination to being unable to cope with knowledge of their "genetic fate." Empirical studies of beliefs about genetic testing suggest tests are likely to be embraced widely, but the studies have methodologic limitations, reducing the certainty of their conclusions, and indicating a need for further research with more representative samples.
引用
收藏
页码:315 / 331
页数:17
相关论文
共 48 条
[1]  
Appelbaum Paul S, 2004, J Psychiatr Pract, V10, P343, DOI 10.1097/00131746-200411000-00002
[2]   The genomic era and serious mental illness: A potential application for psychiatric genetic counseling [J].
Austin, Jehannine C. ;
Honer, William G. .
PSYCHIATRIC SERVICES, 2007, 58 (02) :254-261
[3]   The genomic era and perceptions of psychotic disorders: Genetic risk estimation, associations with reproductive decisions and views about predictive testing [J].
Austin, Jehannine C. ;
Smith, Geoffrey N. ;
Honer, William G. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2006, 141B (08) :926-928
[4]   Civilian and Military Genetics: Nondiscrimination Policy in a Post-GINA World [J].
Baruch, Susannah ;
Hudson, Kathy .
AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 83 (04) :435-444
[5]   Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk. [J].
Bloss, Cinnamon S. ;
Schork, Nicholas J. ;
Topol, Eric J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (06) :524-534
[6]   Factors Associated With Experiences of Genetic Discrimination Among Individuals at Risk for Huntington Disease [J].
Bombard, Yvonne ;
Palin, JoAnne ;
Friedman, Jan M. ;
Veenstra, Gerry ;
Creighton, Susan ;
Paulsen, Jane S. ;
Bottorff, Joan L. ;
Hayden, Michael R. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2011, 156B (01) :19-27
[7]   Clinically responsible genetic testing in neuropsychiatric patients: A bridge too far and too soon [J].
Braff, David L. ;
Freedman, Robert .
AMERICAN JOURNAL OF PSYCHIATRY, 2008, 165 (08) :952-955
[8]   Attitudes of healthcare professionals and parents regarding genetic testing for violent traits in childhood [J].
Campbell, E ;
Ross, LF .
JOURNAL OF MEDICAL ETHICS, 2004, 30 (06) :580-586
[9]   Ethical, legal, and social implications of genomic medicine [J].
Clayton, EW .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (06) :562-569
[10]   Prodromal interventions for schizophrenia vulnerability: the risks of being "at risk" [J].
Corcoran, C ;
Malaspina, D ;
Hercher, L .
SCHIZOPHRENIA RESEARCH, 2005, 73 (2-3) :173-184