Role of creatine kinase and its substrates in the central nervous system in norm and in various pathologies

被引：2

作者：

Nersesova, L. S. ^{[1
]}

机构：

[1] Natl Acad Sci Republ Armenia, Inst Mol Biol, Yerevan, Armenia

来源：

JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY | 2011年 / 47卷 / 02期

关键词：

creatine kinase-creatine phosphate system; creatine; protector action; neurodegenerative diseases; BRAIN CEREBELLUM; MITOCHONDRIAL; SUPPLEMENTATION; GLUTAMATE; DAMAGE; COMPARTMENTATION; NEUROPROTECTION; PHOSPHOKINASE; PROTECTS; HYPOXIA;

D O I：

10.1134/S0022093011020034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is presented review of recent publications providing current understanding of role of creatine kinase-creatine phosphate system and creatine, substrate of creatine kinase, in metabolism of cell and specifically of cells of the central nervous system. Particularly noted are the protector role of creatine at mitochondrial and bioenergetic cell dysfunction and potential significance of creatine bioadditions at treatment of neurodegenerative and other diseases.

引用

页码：140 / 150

页数：11