Role of creatine kinase and its substrates in the central nervous system in norm and in various pathologies

There is presented review of recent publications providing current understanding of role of creatine kinase-creatine phosphate system and creatine, substrate of creatine kinase, in metabolism of cell and specifically of cells of the central nervous system. Particularly noted are the protector role of creatine at mitochondrial and bioenergetic cell dysfunction and potential significance of creatine bioadditions at treatment of neurodegenerative and other diseases.