Nutrition and Gut Immunity

被引：68
作者：
Fukatsu, Kazuhiko [3 ]
Kudsk, Kenneth A. [1 ,2 ]
机构：
[1] Univ Wisconsin Sch Med & Publ Hlth, Dept Surg, Madison, WI 53792 USA
[2] William S Middleton Mem Vet Adm Med Ctr, Vet Adm Surg Serv, Madison, WI USA
[3] Tokyo Univ Hosp, Surg Ctr, Dept Surg, Bunkyo Ku, Tokyo 1138655, Japan
来源：
SURGICAL CLINICS OF NORTH AMERICA | 2011年 / 91卷 / 04期
关键词：
Phospholipase A2; Gut-associated lymphoid tissue; Immunoglobulin A; Glutamine; Mucosal immunity; Enteral nutrition; Parenteral nutrition; TOTAL PARENTERAL-NUTRITION; KAPPA-B ACTIVATION; RESPIRATORY-TRACT IMMUNITY; MAJOR ABDOMINAL-TRAUMA; NECROSIS-FACTOR-ALPHA; CHAIN FATTY-ACIDS; LYMPHOID-TISSUE; MUCOSAL IMMUNITY; IMPROVES SURVIVAL; ESCHERICHIA-COLI;
D O I：
10.1016/j.suc.2011.04.007
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The human intestine contains huge amounts of nonpathologic bacteria surviving in an environment that is beneficial to both the host and the bacterial populations. When short pauses in oral intake occur with minimal alterations in the mucosa-microbial interface, critical illness, with its attendant acidosis, prolonged gastrointestinal tract starvation, exogenous antibiotics, and breakdown in mucosal defenses, renders the host vulnerable to bacterial challenge and also threatens the survival of the bacteria. This review examines the altered innate and adaptive immunologic host defenses that occur as a result of altered oral or enteral intake and/or injury.
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页码：755 / +
页数：17
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