Transforming growth factor-β1 in intrauterine adhesion

被引：58
作者：
Abudukeyoumu, Ayitila [1 ,2 ]
Li, Ming-Qing [1 ,3 ,4 ]
Xie, Feng [1 ,2 ,4 ]
机构：
[1] Fudan Univ, Hosp Obstet & Gynecol, Inst Obstet & Gynecol, Lab Reprod Immunol, Shanghai, Peoples R China
[2] Fudan Univ, Med Ctr Diag & Treatment Cerv Dis, Obstet & Gynecol Hosp, Shanghai, Peoples R China
[3] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Inst Planned Parenthood Res, NHC Key Lab Reprod Regulat, Shanghai, Peoples R China
[4] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Key Lab Female Reprod Endocrine Related, Shanghai, Peoples R China
来源：
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2020年 / 84卷 / 02期
基金：
中国国家自然科学基金;
关键词：
endometrial stem cell; endometrium; estrogen; infertility; Intrauterine adhesion; TGF-beta; 1; GROWTH-FACTOR-BETA; ESTROGEN-RECEPTOR-ALPHA; MESENCHYMAL STEM-CELLS; ENDOMETRIAL FIBROSIS; ASHERMANS-SYNDROME; SIGNALING PATHWAY; UP-REGULATION; RABBIT MODEL; SMAD; EXPRESSION;
D O I：
10.1111/aji.13262
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Intrauterine adhesion (IUA), led by trauma to the basal layer, can prevent the endometrium from growing, resulting in complications in females, such as infertility and amenorrhea. Transforming growth factor-beta 1 (TGF-beta 1) plays a crucial role in inducing and promoting the differentiation and proliferation of mesenchymal cells, in the secretion of extracellular matrix-associated components, and is a major cytokine in initiating and terminating tissue repair downstream of the TGF-beta/Smad signaling pathway. Some evidence supports that TGF-beta 1 is closely associated with the occurrence and development of IUA, and is regarded as an early risk factor of disease recurrence. Furthermore, the role of TGF-beta 1 has been demonstrated to be potentially regulated by a variety of cytokines, hormones, enzymes, and microRNAs. This review provides an overview of the expression, function, and regulation of TGF-beta 1 in IUA, with a brief discussion and perspectives on its future clinical implications on the diagnosis and treatment of IUA.
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收藏
页数：11
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