Ruthenium-Catalyzed E-Selective Alkyne Semihydrogenation with Alcohols as Hydrogen Donors

被引：27

作者：

Ekebergh, Andreas ^{[1
]}

Begon, Romain ^{[1
]}

Kann, Nina ^{[1
]}

机构：

[1] Chalmers Univ Technol, Dept Chem & Chem Engn, Chem & Biochem, SE-41296 Gothenburg, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 05期

基金：

瑞典研究理事会;

关键词：

TRANS-HYDROGENATION; PALLADIUM NANOPARTICLES; REDUCTION; COMPLEXES; SUZUKI;

D O I：

10.1021/acs.joc.9b02721

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Selective direct ruthenium-catalyzed semihydrogenation of diaryl alkynes to the corresponding E-alkenes has been achieved using alcohols as the hydrogen source. The method employs a simple ruthenium catalyst, does not require external ligands, and affords the desired products in > 99% NMR yield in most cases (up to 93% isolated yield). Best results were obtained using benzyl alcohol as the hydrogen donor, although biorenewable alcohols such as furfuryl alcohol could also be applied. In addition, tandem semihydrogena-tionalkylation reactions were demonstrated, with potential applications in the synthesis of resveratrol derivatives.

引用

页码：2966 / 2975

页数：10

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