Interactions of Daphnodorin B and Daphentin with Calf Thymus DNA

被引：0
|
作者：
Li, Qiang [1 ]
Yu, Yanying [1 ,2 ]
Cao, Shuwen [2 ]
机构：
[1] Nanchang Univ, Dept Chem, Nanchang 330031, Peoples R China
[2] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China
来源：
ASIAN JOURNAL OF CHEMISTRY | 2011年 / 23卷 / 09期
关键词：
Daphnodorin B; Daphentin; Calf thymus DNA; Binding; ETHIDIUM-BROMIDE; FLUORESCENCE; BINDING; COMPLEX; PORPHYRINS; PROBE; RED;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interactions of daphnodorin B and daphentin with calf thymus DNA (ctDNA) were investigated. The binding constants of daphnodorin B and daphentin with ctDNA were obtained by UV spectroscopy. Further, the binding mechanisms on the reaction of the two compounds with ctDNA and effect of ionic strength on the fluorescence property of the system have also been investigated. The results of the assay indicate that daphnodorin B intercalates with ctDNA while daphentin interacts with ctDNA by groove binding. And the binding constants of daphnodorin B and daphentin with ctDNA were 3.261 x 10(5) and 1.063 x 10(4) L mol(-1), respectively.
引用
收藏
页码：4138 / 4144
页数：7
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