Cadinane sesquiterpenes from Curcuma phaeocaulis with their inhibitory activities on nitric oxide production in RAW 264.7 cells

被引：19

作者：

Ma, Jianghao ^{[1
]}

Wang, Ying ^{[1
]}

Liu, Yue ^{[1
]}

Gao, Suyu ^{[1
]}

Ding, Liqin ^{[2
]}

Zhao, Feng ^{[3
]}

Chen, Lixia ^{[1
]}

Qiu, Feng ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Dept Nat Prod Chem,Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China

[3] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China

来源：

FITOTERAPIA | 2015年 / 103卷

基金：

中国国家自然科学基金;

关键词：

Curcuma phaeocaulis; Cadinane; Sesquiterpenes; Nitric oxide; Biogenetic pathway; GUAIANE-TYPE SESQUITERPENES; PARVIFLORENE-A; WENYUJIN; DIARYLHEPTANOIDS; KWANGSIENSIS; MACROPHAGES; EXTRACTS; RHIZOMES; LONGA;

D O I：

10.1016/j.fitote.2015.03.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new cadinane-type sesquiterpenes named phacadinanes A-D (1-4) were isolated from the rhizomes of Curcuma phaeocaulis. Their structures were elucidated by 1D and 2D NMR, as well as accurate mass measurements. Compound 4 was the first example of a rare 4,5-seco-cadinane sesquiterpene isolated from the Zingiberaceae family. Furthermore, inhibitory effects of the isolated compounds on nitric oxide production in LPS-activated macrophages were evaluated. Compounds 1 and 2 showed strong inhibitory activities on NO production with IC50 values of 3.88 +/- 058 and 225 +/- 0.71 mu M, respectively. A possible biogenetic pathway for 4,5-seco-cadinane sesquiterpene (4) was postulated. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：90 / 96

页数：7

共 36 条

[1] [Anonymous], J CHIN MED MAT
[2] [Anonymous], 2017, PHARM, V524, P257
[3] Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells
Chen, Xiuping
Pei, Lixia
Zhong, Zhangfeng
Guo, Jiajie
Zhang, Qingwen
Wang, Yitao
[J]. PHYTOMEDICINE, 2011, 18 (14) : 1238 - 1243
[4] PYRIDINE-INDUCED SOLVENT SHIFTS IN NUCLEAR MAGNETIC RESONANCE SPECTRA OF HYDROXYLIC COMPOUNDS
DEMARCO, PV
FARKAS, E
DODDRELL, D
MYLARI, BL
WENKERT, E
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1968, 90 (20) : 5480 - &
[5] Dewick PM, 2008, MED NATURAL PRODUCTS, P21
[6] Twelve new compounds from the basidiomycete Boreostereum vibrans
Jian-Hai Ding
Tao Feng
Zheng-Hui Li
Liang Li
Ji-Kai Liu
[J]. Natural Products and Bioprospecting, 2012, 2 (5) : 200 - 205
[7] The Griess assay: Suitable for a bio-guided fractionation of anti-inflammatory plant extracts?
Dirsch, VM
Stuppner, H
Vollmar, AM
[J]. PLANTA MEDICA, 1998, 64 (05) : 423 - 426
[8] Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities
Dong, Jian-Yong
Ma, Xi-Yan
Cai, Xiao-Qin
Yan, Peng-Cheng
Yue, Lei
Lin, Chen
Shao, Wei-Wei
[J]. PHYTOCHEMISTRY, 2013, 85 : 122 - 128
[9] Two New Sesquiterpenes from Acorus calamus
Dong, Weiwei
Li, Minjie
Yang, Dajian
Lu, Runhua
[J]. PLANTA MEDICA, 2010, 76 (15) : 1742 - 1745
[10] Geoffrey DB, 2004, TETRAHEDRON, V60, P1125

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