Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming

被引：46
作者：
Fang, Jun [3 ,4 ]
Hsueh, Yuan-Yu [3 ,5 ]
Soto, Jennifer [3 ,4 ]
Sun, Wujin [2 ,3 ]
Wang, Jinqiang [2 ,3 ]
Gu, Zhen [2 ,3 ,6 ]
Khademhosseini, Ali [3 ,7 ,8 ]
Li, Song [1 ,2 ]
机构：
[1] Univ Calif Los Angeles, Calif NanoSyst Inst, Dept Med, Dept Bioengn, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Calif NanoSyst Inst, C MIT, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA
[5] Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg, Div Plast Surg, Tainan 70456, Taiwan
[6] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA
[7] Univ Calif Los Angeles, Calif NanoSyst Inst, C MIT, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA
[8] Univ Calif Los Angeles, Dept Radiol, Los Angeles, CA 90095 USA
来源：
ACS NANO | 2020年 / 14卷 / 02期
基金：
美国国家卫生研究院;
关键词：
cell reprogramming; biomaterials; nanotechnology; biophysical cues; biochemical cues; three-dimensional niches; tissue engineering; drug delivery; PLURIPOTENT STEM-CELLS; ON-A-CHIP; IN-VIVO; HUMAN FIBROBLASTS; DIRECT CONVERSION; FUNCTIONAL-NEURONS; MOUSE FIBROBLASTS; PROGENITOR CELLS; SOMATIC-CELLS; GENE-THERAPY;
D O I：
10.1021/acsnano.9b04837
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cell reprogramming is a revolutionized biotechnology that offers a powerful tool to engineer cell fate and function for regenerative medicine, disease modeling, drug discovery, and beyond. Leveraging advances in biomaterials and micro/ nanotechnologies can enhance the reprogramming performance in vitro and in vivo through the development of delivery strategies and the control of biophysical and biochemical cues. In this review, we present an overview of the state-of-the-art technologies for cell reprogramming and highlight the recent breakthroughs in engineering biomaterials with micro/nanotechnologies to improve reprogramming efficiency and quality. Finally, we discuss future directions and challenges for reprogramming technologies and clinical translation.
引用
收藏
页码：1296 / 1318
页数：23
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