IN-VITRO TRANSFECTION OF ANTI-TUMOR miR-101 INDUCES BIM, A PRO-APOPTOTIC PROTEIN, EXPRESSION IN ACUTE MYELOID LEUKEMIA (AML)

被引：6

作者：

Lotfabadi, Narges Nikoonahad ^{[1
,2
]}

Kouchesfahani, Homa Mohseni ^{[1
]}

Sheikhha, Mohammad Hasan ^{[3
,4
]}

Kalantar, Seyed Mehdi ^{[3
]}

机构：

[1] Kharazmi Univ, Fac Biol Sci, Dept Anim Biol, Tehran, Iran

[2] Sci & Arts Univ, Dept Biol, Fac Sci, Yazd, Iran

[3] Shahid Sadoughi Univ Med Sci, Res & Clin Ctr Infertil, Reprod & Genet Unit, Yazd, Iran

[4] Shahid Sadoughi Univ Med Sci, Biotechnol Res Ctr, Int Campus, Yazd, Iran

来源：

EXCLI JOURNAL | 2017年 / 16卷

关键词：

AML; miR-101; BIM; apoptosis; CELL LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; PROMOTES APOPTOSIS; DOWN-REGULATION; MICRORNA-101; MCL-1; PROLIFERATION; INVASION; DELIVERY; THERAPY;

D O I：

10.17179/excli2017-721

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Acute myeloid leukemia (AML) frequently relapses after initial treatment, though it is possible that drug resistance occurs. Hence, it seems necessary to develop novel therapies such as gene therapy specifically via miRNA transfection. MicroRNA-101 has been considered as a tumor suppressor in different types of cancer. It is demonstrated that exogenous miR-101 transfection is associated with decreased viability in AML in this paper. Besides, the increase of pro-apoptotic protein BIM expression in both mRNA and protein level has been illustrated. The recent findings provide an insight into the novel function of miR-101 in AML by activating BIM as an important mediator in intrinsic apoptosis pathways. Generally, miR-101 has been considered as a therapeutic target in our data and might have a valuable role in AML.

引用

页码：1257 / 1267

页数：11

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