Synthesis and crystal structure of topiramate azidosulfate at 90 K and 298 K

被引：0

作者：

Priyanka, Prabhakar ^{[1
]}

Jayanna, Bidarur K. ^{[1
]}

Kumar, Haruvegowda Kiran ^{[2
]}

Vinaya ^{[2
]}

Divakara, Thayamma R. ^{[3
]}

Yathirajan, Hemmige S. ^{[2
]}

Glidewell, Christopher ^{[4
]}

Parkin, Sean ^{[5
]}

机构：

[1] BNM Inst Technol, Dept Chem, Bengaluru 560070, India

[2] Univ Mysore, Dept Studies Chem, Manasagangotri 570006, Mysuru, India

[3] T John Inst Technol, Bengaluru 560083, India

[4] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

[5] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2022年 / 78卷

关键词：

topiramate azidosulfate; inter-mediate; anti-convulsant; crystal structure; absolute configuration; INTRAMOLECULAR MOTIONS; CONFORMATION; BROMIDES;

D O I：

10.1107/S2056989022008799

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The low (90 K) and room (298 K) temperature crystal structures of topiramate azidosulfate [systematic name 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose azidosulfate], C12H19N3O8S, an intermediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azidosulfate (I) finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented.

引用

页码：984 / +

页数：15

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