Mitochondrial DNA protects against salt stress-induced cytochrome c-mediated apoptosis in yeast

被引：18

作者：

Gao, Qiuqiang ^{[1
,2
]}

Ren, Qun ^{[2
]}

Liou, Liang-Chun ^{[2
]}

Bao, Xiaoming ^{[1
]}

Zhang, Zhaojie ^{[2
]}

机构：

[1] Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China

[2] Univ Wyoming, Dept Zool & Physiol, Laramie, WY 82071 USA

来源：

FEBS LETTERS | 2011年 / 585卷 / 15期

关键词：

Apoptosis; Cytochrome c; Mitochondrial DNA; Salt stress; Saccharomyces cerevisiae; PROGRAMMED CELL-DEATH; OXIDATIVE STRESS; ACETIC-ACID; ACTIVATION; MEIOSIS; RELEASE; PATHWAY; MARKERS;

D O I：

10.1016/j.febslet.2011.06.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we report that budding yeast mitochondrial DNA protects against salt stress-induced apoptosis. Yeast cells lacking mitochondrial DNA (rho(0)) are hypersensitive to salt stress-induced apoptosis, which is mediated by mitochondrial cytochrome c release. In addition, cytochrome c expression is downregulated upon salt stress, suggesting a transcriptionally regulated, homeostatic protection mechanism. The repression of cytochrome c transcription is mediated by transcription factor Mig1. Consistently, deletion of MIG1 induces cytochrome C transcription and yields rho(0) cells that are more sensitive to salt stress. In summary, deletion of mitochondrial function leads to salt stress-induced transcriptional deregulation of cytochrome C, causing apoptosis in yeast. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2507 / 2512

页数：6

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