Design of phosphonium ionic liquids for lipase-catalyzed transesterification

被引：66

作者：

Abe, Yoshikazu ^{[1
]}

Kude, Keisuke ^{[1
]}

Hayase, Shuichi ^{[1
]}

Kawatsura, Motoi ^{[1
]}

Tsunashima, Katsuhiko ^{[2
]}

Itoh, Toshiyuki ^{[1
]}

机构：

[1] Tottori Univ, Fac Engn, Dept Mat Sci, Tottori 6808552, Japan

[2] Nippon Chem Ind Co Ltd, Koto Ku, Tokyo 1368515, Japan

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2008年 / 51卷 / 3-4期

关键词：

ionic liquid; phosphonium salt; lipase; transesterification; rapid reaction;

D O I：

10.1016/j.molcatb.2007.11.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ionic liquids are now recognized as solvents for use in lipase-catalyzed reactions; however, there still remains a serious drawback in that the rate of reaction in an ionic liquid is slower than that in a conventional organic solvent. To overcome this problem, attempts have been made to evolve phosphonium ionic liquids appropriate for lipase-catalyzed reaction; several types of phosphonium salts have been prepared and their capability evaluated for use as solvent for the lipase-catalyzed reaction. Very rapid lipase PS-catalyzed transesterification of secondary alcohols was obtained when 2-methoxyethyl(tri-n-butyl)phosphonium bis(trifluoromethanesulfonyl)imide ([MEBu3P][NTf2]) was used as solvent, affording the first example of a reaction rate superior to that in diisopropyl ether. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：81 / 85

页数：5

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