Effects of Puerarin on the Prevention and Treatment of Cardiovascular Diseases

被引:63
|
作者
Zhou, Yan-Xi [1 ,2 ]
Zhang, Hong [3 ]
Peng, Cheng [1 ]
机构
[1] Chengdu Univ Tradit Chinese Med, Coll Pharm, State Key Lab Characterist Chinese Med Resources, Chengdu, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Lib, Chengdu, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Med Sci, Shanghai, Peoples R China
关键词
puerarin; cardiovascular diseases; mechanisms; targets; clinical trials; NF-KAPPA-B; ISCHEMIA-REPERFUSION INJURY; TRADITIONAL CHINESE MEDICINE; INDUCED CARDIAC-HYPERTROPHY; CEREBRAL-ISCHEMIA; MYOCARDIAL-ISCHEMIA; INSULIN-RESISTANCE; LYOPHILIZED POWDER; PRESSURE-OVERLOAD; OXIDATIVE STRESS;
D O I
10.3389/fphar.2021.771793
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Puerarin, an isoflavone glycoside derived from Pueraria lobata (Willd.) Ohwi, has been identified as a pharmacologically active component with diverse benefits. A large number of experimental and clinical studies have demonstrated that puerarin is widely used in the treatment of a variety of diseases. Among them, cardiovascular diseases (CVDs) are the leading cause of death in the world, and therefore remain one of the most prominent global public health concerns. In this review, we systematically analyze the preclinical investigations of puerarin in CVDs, such as atherosclerosis, cardiac hypertrophy, heart failure, diabetic cardiovascular complications, myocardial infarction, stroke and hypertension. In addition, the potential molecular targets of puerarin are also discussed. Furthermore, we summarize the clinical trails of puerarin in the treatment of CVDs. Finally, the therapeutic effects of puerarin derivatives and its drug delivery systems are overviewed.
引用
收藏
页数:18
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