The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

被引：46

作者：

Koo, Ja Seung ^{[2
]}

Park, Seho ^{[1
]}

Kim, Seung Il ^{[1
]}

Lee, Sarah ^{[2
]}

Park, Byeong-Woo ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Severance Hosp, Dept Surg, Seoul, South Korea

[2] Yonsei Univ, Coll Med, Dept Pathol, Seoul, South Korea

来源：

TUMOR BIOLOGY | 2011年 / 32卷 / 04期

关键词：

Breast cancer; Caveolin; Immunohistochemistry; Stroma; BASAL-LIKE; OXIDATIVE STRESS; FIBROBLASTS; GROWTH; THERAPY; CELLS; PROGRESSION; PHENOTYPE;

D O I：

10.1007/s13277-011-0181-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We aimed to investigate the expression of caveolin-1, -2, -3, and platelet-derived growth factor (PDGF) beta receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF beta receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p < 0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p < 0.001), high nodal stage (p = 0.011), high cancer stage (p = 0.005), estrogen receptor negativity (p = 0.003), and tumor recurrence (p = 0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p < 0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.

引用

页码：787 / 799

页数：13

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