The paper presents a theoretical and applied research that investigates the structural components of an urban portion of the "Tuscolano" neighborhood in Rome. So that, this contribute analyze on the one hand the morpho-typological aspects of urban fabrics and the local climate, on the other hand reflect on the potential implications of the urban form in terms of health and well-being of the inhabitants. The study join with the debate on the urban development planning careful to the quality of life and the territory demand, which is increasingly explicit at a national/international level, for healthier, fairer and more inclusive cities. To this end, the study analyzes two opposite urban structures of the "Tuscolana" road axis that divides and connect two different urban context: on one side the high-density fabrics of private buildings and on the other historical examples of Social Housing such as the "INA-Casa Plan" of the fifties. The digital elaborations examine, through multi-scale and multi-disciplinary Scientific Indices, the specific characters of this densely urbanized area which nevertheless maintain a high historical-identity and landscape-cultural value. In consequence, the research produces: i) a socio-climatic-morphological profile through data/tools referable to the field of GIScience; ii) food for thought on the role of the public/private open space system as an infrastructure capable of facing the current health and climatic emergencies and also as a fertile ground for experimentation. In conclusion, the research proposes a geo-informatics workflow to be combine with current cognitive tools so as to implement "new" knowledge bases and support decision-making processes. As a result, the research perform a case study using objective and qualitative- quantitative analyzes, with which could be possible to hypothesize different evolutionary, adaptive, resilient and eco-oriented scenarios in order to protect the health of citizens as well as the quality of the urban space.
