Use of (S)-5-(2-methylpyrrolidin-2-yl)-1H-tetrazole as a novel and enantioselective organocatalyst for the aldol reaction

被引：31

作者：

Tong, Sok-Teng ^{[1
]}

Harris, Paul W. R. ^{[1
]}

Barker, David ^{[1
]}

Brimble, Margaret A. ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland 1142, New Zealand

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 01期

关键词：

aldol; enantioselectivity; methylproline; organocatalysis; tetrazole;

D O I：

10.1002/ejoc.200700834

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel organocatalyst (S)-5-(2-methylpyrrohdin-2-yl)-1H-tetrazole (4) catalyzes the aldol reaction between acetone and various aldehydes with superior enantioselectivity to the existing organocatalysts (S)-prohne (1) and (S)-5-(pyrrohdin2-yl)-1H-tetrazole (3). ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).

引用

页码：164 / 170

页数：7

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