Location, location, location: The cancer stem cell niche

被引：137

作者：

Sneddon, Julie B. ^{[1
,2
]}

Werb, Zena ^{[3
]}

机构：

[1] Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA

[2] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[3] Univ Calif San Francisco, Dept Anat, Ctr Comprehens Canc, San Francisco, CA 94143 USA

来源：

CELL STEM CELL | 2007年 / 1卷 / 06期

关键词：

D O I：

10.1016/j.stem.2007.11.009

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The existence of a stem cell niche, or physiological microenvironment, consisting of specialized cells that directly and indirectly participate in stem cell regulation has been verified for mammalian adult stem cells in the intestinal, neural, epidermal, and hernatopoietic systems. In light of these findings, it has been proposed that a "cancer stem cell niche" also exists and that interactions with this tumor niche may specify a self-renewing population of tumor cells. We discuss emerging data that support the idea of a veritable cancer stem cell niche and propose several models for the relationship between cancer cells and their niches.

引用

页码：607 / 611

页数：5

共 24 条

[1] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2]

Barcellos-Hoff MH, 2000, CANCER RES, V60, P1254

[3] The hypoxic response of tumors is dependent on their microenvironment [J].

Blouw, B ;

Song, HQ ;

Tihan, T ;

Bosze, J ;

Ferrara, N ;

Gerber, HP ;

Johnson, RS ;

Bergers, G .

CANCER CELL, 2003, 4 (02) :133-146

[4] A perivascular niche for brain tumor stem cells [J].

Calabrese, Christopher ;

Poppleton, Helen ;

Kocak, Mehmet ;

Hogg, Twala L. ;

Fuller, Christine ;

Hamner, Blair ;

Oh, Eun Young ;

Gaber, M. Waleed ;

Finklestein, David ;

Allen, Meredith ;

Frank, Adrian ;

Bayazitov, Ildar T. ;

Zakharenko, Stanislav S. ;

Gajjar, Amar ;

Davidoff, Andrew ;

Gilbertson, Richard J. .

CANCER CELL, 2007, 11 (01) :69-82

[5] New signals from the invasive front [J].

Christofori, G .

NATURE, 2006, 441 (7092) :444-450

[6] A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia [J].

De Toni, F. ;

Racaud-Sultan, C. ;

Chicanne, G. ;

Mansat-De Mas, V. ;

Cariven, C. ;

Mesange, F. ;

Salles, J-P ;

Demur, C. ;

Allouche, M. ;

Payrastre, B. ;

Manenti, S. ;

Ysebaert, L. .

ONCOGENE, 2006, 25 (22) :3113-3122

[7] Destemming cancer stem cells [J].

Hill, Richard P. ;

Perris, Roberto .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (19) :1435-1440

[8] Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity [J].

Hope, KJ ;

Jin, LQ ;

Dick, JE .

NATURE IMMUNOLOGY, 2004, 5 (07) :738-743

[9] Mutations in the SMAD4/DPC4 gene in juvenile polyposis [J].

Howe, JR ;

Roth, S ;

Ringold, JC ;

Summers, RW ;

Järvinen, HJ ;

Sistonen, P ;

Tomlinson, IPM ;

Houlston, RS ;

Bevan, S ;

Mitros, FA ;

Stone, EM ;

Aaltonen, LA .

SCIENCE, 1998, 280 (5366) :1086-1088

[10] A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature [J].

Jin, H ;

Aiyer, A ;

Su, JM ;

Borgstrom, P ;

Stupack, D ;

Friedlander, M ;

Varner, J .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (03) :652-662

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