Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms

被引：71

作者：

Manning, Sean ^{[1
,2
]}

Pucci, Andrea ^{[1
,3
,4
]}

Batterham, Rachel L. ^{[1
,3
,4
]}

机构：

[1] UCL, Dept Med, Rayne Inst, Obes Res Ctr, London WC1E 6JJ, England

[2] Natl Univ Ireland Univ Coll Cork, Sch Med, Cork, Ireland

[3] Univ Coll London Hosp, Ctr Weight Loss Metab & Endocrine Surg, London, England

[4] Univ Coll London Hosp, Biomed Res Ctr, Natl Inst Hlth Res, London, England

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2015年 / 125卷 / 03期

关键词：

GLUCAGON-LIKE PEPTIDE-1; RESTING ENERGY-EXPENDITURE; INDUCED WEIGHT-LOSS; FOOD-INTAKE; BARIATRIC SURGERY; GLUCOSE-HOMEOSTASIS; GUT HORMONE; MELANOCORTIN-4; RECEPTOR; BRAIN ACTIVITY; BILE-ACIDS;

D O I：

10.1172/JCI76305

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bariatric surgery is the most effective treatment for severe obesity, producing marked sustained weight loss with associated reduced morbidity and mortality. Roux-en-Y gastric bypass surgery (RYGBP), the most commonly performed procedure, was initially viewed as a hybrid restrictive-malabsorptive procedure. However, over the last decade, it has become apparent that alternative physiologic mechanisms underlie its beneficial effects. RYGBP-induced altered feeding behavior, including reduced appetite and changes in taste/food preferences, is now recognized as a key driver of the sustained postoperative weight loss. The brain ultimately determines feeding behavior, and here we review the mechanisms by which RYGBP may affect central appetite-regulating pathways.

引用

页码：939 / 948

页数：10

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