Truncateols O-V, further isoprenylated cyclohexanols from the sponge-associated fungus Truncatella angustata with antiviral activities

被引：28

作者：

Zhao, Yang ^{[1
]}

Liu, Dong ^{[1
]}

Proksch, Peter ^{[2
]}

Zhou, Demin ^{[1
]}

Lin, Wenhan ^{[1
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Heinrich Heine Univ, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

来源：

PHYTOCHEMISTRY | 2018年 / 155卷

基金：

中国国家自然科学基金;

关键词：

Truncatella angustata; Amphisphaeriaceae; Marine-derived fungus; Truncateols O-V; Anti-HIV-1; activity; Anti-H-1-N-1; FELINA KMM 4639; ABSOLUTE-CONFIGURATION; MARINE; OXIRAPENTYNS; MO-2(OAC)(4); ASSIGNMENT; 1,2-DIOLS; MICROBES; DRUGS;

D O I：

10.1016/j.phytochem.2018.07.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical examination of the EtOAc extract of the sponge-associated fungus Truncatella angustata in solid culture led to the isolation of eight undescribed isoprenylated cyclohexanols, namely truncateols O-V together with 14 known analogues. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method and ECD data for the assignment of their absolute configurations. Truncateol O exhibited significant inhibition toward both HIV-1 and H1N1 virus, while truncateol P exerted inhibitory effect against HIV-1 virus.

引用

页码：61 / 68

页数：8

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