Adaptive designs for normal responses with prognostic factors

被引:79
作者
Bandyopadhyay, U
Biswas, A
机构
[1] Univ Calcutta, Dept Stat, Kolkata 700019, W Bengal, India
[2] Indian Stat Inst, Appl Stat Unit, Kolkata 700035, W Bengal, India
关键词
balanced design; biased coin design; efficiency; limiting proportion of allocation; probit link;
D O I
10.1093/biomet/88.2.409
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Adaptive designs are often used in clinical trials to force balance in sequential allocation of patients between two or more competitive treatments. Sometimes, from ethical considerations, the goal may be to allocate a larger number of patients to the better treatment in the course of the trial. In the present paper we consider patients who are heterogeneous with respect to some prognostic factors and assume that the response from each patient is a continuous variable. We consider a normal linear model and provide an allocation design with due attention to the prognostic factors. The loss of efficiency incurred by using a balanced design is also indicated. Issues of inference based on adaptive allocation are also discussed. Finally a guideline is provided for the appropriate choice of the design parameters.
引用
收藏
页码:409 / 419
页数:11
相关论文
共 15 条
[1]   OPTIMUM BIASED COIN DESIGNS FOR SEQUENTIAL CLINICAL-TRIALS WITH PROGNOSTIC FACTORS [J].
ATKINSON, AC .
BIOMETRIKA, 1982, 69 (01) :61-67
[2]  
Atkinson AC, 1999, STAT MED, V18, P1741, DOI 10.1002/(SICI)1097-0258(19990730)18:14<1741::AID-SIM210>3.0.CO
[3]  
2-F
[4]  
Atkinson AC, 1999, TATRA MOUNTAINS MATH, V17, P133
[5]  
Bandyopadhyay U., 1999, SANKHYA SER, V61, P397
[6]  
BARTLETT RH, 1985, PEDIATRICS, V76, P479
[7]   TREATMENT ALLOCATION PROCEDURE FOR SEQUENTIAL CLINICAL-TRIALS [J].
BEGG, CB ;
IGLEWICZ, B .
BIOMETRICS, 1980, 36 (01) :81-90
[8]  
EFRON B, 1971, BIOMETRIKA, V58, P403, DOI 10.2307/2334377
[9]  
FORD I, 1980, BIOMETRIKA, V67, P381, DOI 10.1093/biomet/67.2.381
[10]  
Rosenberger WF, 1996, STAT SCI, V11, P137