Genomic salmon testes DNA as a catalyst for Michael reactions in water

被引：17
作者：
De Rosa, Margherita [1 ]
Di Marino, Sara [2 ]
D'Ursi, Anna Maria [2 ]
Strianese, Maria [1 ]
Soriente, Annunziata [1 ]
机构：
[1] Univ Salerno, Dept Biol & Chem, I-84084 Fisciano, SA, Italy
[2] Univ Salerno, Dept Pharmaceut & Biomed Sci, I-84084 Fisciano, SA, Italy
来源：
TETRAHEDRON | 2012年 / 68卷 / 14期
关键词：
Catalysis; DNA; Water; Michael addition; Fluorescence spectrometry; ALDEHYDES; ADDITIONS; ACCELERATION; NITROALKENES; REACTIVITY; SOLVENT; KETONES;
D O I：
10.1016/j.tet.2012.02.007
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The DNA molecule, recognized as the carrier of genetic information in vivo, can function as an efficient organocatalyst for Michael additions of 1,3-dicarbonyl compounds to activated alkenes in aqueous media. The procedure described here is environmentally benign and offers several advantages in terms of simplicity, generality and efficiency. We have used fluorescence spectroscopy to evaluate the catalytic activity of a molecule of DNA. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3086 / 3091
页数：6
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